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NIR‐Triggered Crystal Phase Transformation of NiTi‐Layered Double Hydroxides Films for Localized Chemothermal Tumor Therapy

Construction of localized drug‐eluting systems with synergistic chemothermal tumor‐killing abilities is promising for biomedical implants directly contacting with tumor tissues. In this study, an intelligent and biocompatible drug‐loading platform, based on a gold nanorods‐modified butyrate‐inserted...

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Detalles Bibliográficos
Autores principales: Wang, Donghui, Ge, Naijian, Yang, Tingting, Peng, Feng, Qiao, Yuqin, Li, Qianwen, Liu, Xuanyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908485/
https://www.ncbi.nlm.nih.gov/pubmed/29721424
http://dx.doi.org/10.1002/advs.201700782
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author Wang, Donghui
Ge, Naijian
Yang, Tingting
Peng, Feng
Qiao, Yuqin
Li, Qianwen
Liu, Xuanyong
author_facet Wang, Donghui
Ge, Naijian
Yang, Tingting
Peng, Feng
Qiao, Yuqin
Li, Qianwen
Liu, Xuanyong
author_sort Wang, Donghui
collection PubMed
description Construction of localized drug‐eluting systems with synergistic chemothermal tumor‐killing abilities is promising for biomedical implants directly contacting with tumor tissues. In this study, an intelligent and biocompatible drug‐loading platform, based on a gold nanorods‐modified butyrate‐inserted NiTi‐layered double hydroxides film (Au@LDH/B), is prepared on the surface of nitinol alloy. The prepared films function as drug‐loading “sponges,” which pump butyrate out under near‐infrared (NIR) irradiation and resorb drugs in water when the NIR laser is shut off. The stimuli‐responsive release of butyrate is verified to be related with the NIR‐triggered crystal phase transformation of Au@LDH/B. In vitro and in vivo studies reveal that the prepared films possess excellent biosafety and high efficiency in synergistic thermochemo tumor therapy, showing a promising application in the construction of localized stimuli‐responsive drug‐delivery systems.
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spelling pubmed-59084852018-05-02 NIR‐Triggered Crystal Phase Transformation of NiTi‐Layered Double Hydroxides Films for Localized Chemothermal Tumor Therapy Wang, Donghui Ge, Naijian Yang, Tingting Peng, Feng Qiao, Yuqin Li, Qianwen Liu, Xuanyong Adv Sci (Weinh) Full Papers Construction of localized drug‐eluting systems with synergistic chemothermal tumor‐killing abilities is promising for biomedical implants directly contacting with tumor tissues. In this study, an intelligent and biocompatible drug‐loading platform, based on a gold nanorods‐modified butyrate‐inserted NiTi‐layered double hydroxides film (Au@LDH/B), is prepared on the surface of nitinol alloy. The prepared films function as drug‐loading “sponges,” which pump butyrate out under near‐infrared (NIR) irradiation and resorb drugs in water when the NIR laser is shut off. The stimuli‐responsive release of butyrate is verified to be related with the NIR‐triggered crystal phase transformation of Au@LDH/B. In vitro and in vivo studies reveal that the prepared films possess excellent biosafety and high efficiency in synergistic thermochemo tumor therapy, showing a promising application in the construction of localized stimuli‐responsive drug‐delivery systems. John Wiley and Sons Inc. 2018-02-07 /pmc/articles/PMC5908485/ /pubmed/29721424 http://dx.doi.org/10.1002/advs.201700782 Text en © 2018 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Full Papers
Wang, Donghui
Ge, Naijian
Yang, Tingting
Peng, Feng
Qiao, Yuqin
Li, Qianwen
Liu, Xuanyong
NIR‐Triggered Crystal Phase Transformation of NiTi‐Layered Double Hydroxides Films for Localized Chemothermal Tumor Therapy
title NIR‐Triggered Crystal Phase Transformation of NiTi‐Layered Double Hydroxides Films for Localized Chemothermal Tumor Therapy
title_full NIR‐Triggered Crystal Phase Transformation of NiTi‐Layered Double Hydroxides Films for Localized Chemothermal Tumor Therapy
title_fullStr NIR‐Triggered Crystal Phase Transformation of NiTi‐Layered Double Hydroxides Films for Localized Chemothermal Tumor Therapy
title_full_unstemmed NIR‐Triggered Crystal Phase Transformation of NiTi‐Layered Double Hydroxides Films for Localized Chemothermal Tumor Therapy
title_short NIR‐Triggered Crystal Phase Transformation of NiTi‐Layered Double Hydroxides Films for Localized Chemothermal Tumor Therapy
title_sort nir‐triggered crystal phase transformation of niti‐layered double hydroxides films for localized chemothermal tumor therapy
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908485/
https://www.ncbi.nlm.nih.gov/pubmed/29721424
http://dx.doi.org/10.1002/advs.201700782
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