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Metaplastic breast carcinoma composed of epithelial–myoepithelial carcinoma and squamous cell carcinoma: A case report
RATIONALE: Metaplastic breast carcinomas are a group of breast malignancies with varying histomorphological characteristics and prognoses. The tumor composed of epithelial -myoepithelial carcinoma and squamous cell carcinoma was not reported previously. PATIENT CONCERNS: An 81-year-old woman present...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908572/ https://www.ncbi.nlm.nih.gov/pubmed/29642184 http://dx.doi.org/10.1097/MD.0000000000010364 |
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author | Zhu, Jian Li, Kainan Dong, Xuefeng Zhou, Peng Li, Peifeng Bi, Jingwang |
author_facet | Zhu, Jian Li, Kainan Dong, Xuefeng Zhou, Peng Li, Peifeng Bi, Jingwang |
author_sort | Zhu, Jian |
collection | PubMed |
description | RATIONALE: Metaplastic breast carcinomas are a group of breast malignancies with varying histomorphological characteristics and prognoses. The tumor composed of epithelial -myoepithelial carcinoma and squamous cell carcinoma was not reported previously. PATIENT CONCERNS: An 81-year-old woman presented with a palpable nodule in the left breast for 4 days. The ultrasonography showed multinodular growth and focally indistinct borders. Owing to her advanced age and possible early clinical staging, primary tumor resection was performed. One year later, a small and slow growing subcutaneous nodule was found under the incision of the left breast. Ultrasonography revealed an irregular, cystic and solid, hypoechoic mass with circumscribed borders. DIAGNOSES: Microscopic examination of the primary tumor revealed epithelial -myoepithelial carcinoma and squamous cell carcinoma. The former had a variety of architecture patterns, including nests, lobulations, papillary and tubular structures, and the latter showed varying morphological features, from squamous pearls to spindle cells. The recurrent tumor showed only epithelial -myoepithelial carcinoma with more aggressively malignant features than those seen in the primary tumor. INTERVENTIONS: An extensive resection of the left breast mass was performed for the recurrent tumor. The patient did not receive any adjuvant chemotherapy or radiation therapy because of the patient's advanced age. OUTCOMES: The patient has been followed up for 1.5 years after second surgery without evidence of tumor recurrence and metastasis. LESSONS: Wide local excision with adequate margins is recommended for elderly patients with metaplastic breast carcinoma composed of epithelial -myoepithelial carcinoma and squamous cell carcinoma. |
format | Online Article Text |
id | pubmed-5908572 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-59085722018-04-30 Metaplastic breast carcinoma composed of epithelial–myoepithelial carcinoma and squamous cell carcinoma: A case report Zhu, Jian Li, Kainan Dong, Xuefeng Zhou, Peng Li, Peifeng Bi, Jingwang Medicine (Baltimore) 5750 RATIONALE: Metaplastic breast carcinomas are a group of breast malignancies with varying histomorphological characteristics and prognoses. The tumor composed of epithelial -myoepithelial carcinoma and squamous cell carcinoma was not reported previously. PATIENT CONCERNS: An 81-year-old woman presented with a palpable nodule in the left breast for 4 days. The ultrasonography showed multinodular growth and focally indistinct borders. Owing to her advanced age and possible early clinical staging, primary tumor resection was performed. One year later, a small and slow growing subcutaneous nodule was found under the incision of the left breast. Ultrasonography revealed an irregular, cystic and solid, hypoechoic mass with circumscribed borders. DIAGNOSES: Microscopic examination of the primary tumor revealed epithelial -myoepithelial carcinoma and squamous cell carcinoma. The former had a variety of architecture patterns, including nests, lobulations, papillary and tubular structures, and the latter showed varying morphological features, from squamous pearls to spindle cells. The recurrent tumor showed only epithelial -myoepithelial carcinoma with more aggressively malignant features than those seen in the primary tumor. INTERVENTIONS: An extensive resection of the left breast mass was performed for the recurrent tumor. The patient did not receive any adjuvant chemotherapy or radiation therapy because of the patient's advanced age. OUTCOMES: The patient has been followed up for 1.5 years after second surgery without evidence of tumor recurrence and metastasis. LESSONS: Wide local excision with adequate margins is recommended for elderly patients with metaplastic breast carcinoma composed of epithelial -myoepithelial carcinoma and squamous cell carcinoma. Wolters Kluwer Health 2018-04-13 /pmc/articles/PMC5908572/ /pubmed/29642184 http://dx.doi.org/10.1097/MD.0000000000010364 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 5750 Zhu, Jian Li, Kainan Dong, Xuefeng Zhou, Peng Li, Peifeng Bi, Jingwang Metaplastic breast carcinoma composed of epithelial–myoepithelial carcinoma and squamous cell carcinoma: A case report |
title | Metaplastic breast carcinoma composed of epithelial–myoepithelial carcinoma and squamous cell carcinoma: A case report |
title_full | Metaplastic breast carcinoma composed of epithelial–myoepithelial carcinoma and squamous cell carcinoma: A case report |
title_fullStr | Metaplastic breast carcinoma composed of epithelial–myoepithelial carcinoma and squamous cell carcinoma: A case report |
title_full_unstemmed | Metaplastic breast carcinoma composed of epithelial–myoepithelial carcinoma and squamous cell carcinoma: A case report |
title_short | Metaplastic breast carcinoma composed of epithelial–myoepithelial carcinoma and squamous cell carcinoma: A case report |
title_sort | metaplastic breast carcinoma composed of epithelial–myoepithelial carcinoma and squamous cell carcinoma: a case report |
topic | 5750 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908572/ https://www.ncbi.nlm.nih.gov/pubmed/29642184 http://dx.doi.org/10.1097/MD.0000000000010364 |
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