Hydroa vacciniforme-like cutaneous T-cell lymphoma in a child: A case report

RATIONALE: Hydroa vacciniforme (HV)-like T-cell lymphoma is a rare malignancy in childhood associated with Epstein-Barr virus infection. PATIENT CONCERNS: A 6-year old girl presented with complaint of 3-year history of recurrent skin lesions, 3 months of fever accompanied by cough for 8 days. DIAGNOSES: Skin biopsy revealed a HV-like lymphoma presentation and positive signals of EBER were detected by in situ hybridization. TCR-γ gene monoclonal rearrangement was present. A HV-like cutaneous T-cell lymphoma was diagnosed. INTERVENTIONS: The girl was treated with cyclosporine and CHOP. OUTCOMES: The girl's condition had been stable for 6 months. LESSONS: Our case highlights the necessity for taking the HV-like lymphoma as a differential diagnosis especially when a patient manifests as recurrent skin lesions accompanied by systemic involvement.