Cargando…
Association between interleukin 37 (rs3811047) polymorphism and multiple autoimmune diseases in a Chinese population: A PRISMA-compliant meta-analysis
OBJECTIVE: Emerging evidence suggests that interleukin 37 (IL-37) plays an important role in the pathogenesis of several autoimmune diseases (ADs), but the correlations are still unclear. We conducted a meta-analysis to explore whether IL-37 gene (rs3811047) polymorphism was associated with suscepti...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908614/ https://www.ncbi.nlm.nih.gov/pubmed/29642198 http://dx.doi.org/10.1097/MD.0000000000010386 |
_version_ | 1783315745363460096 |
---|---|
author | Lin, Xiao-Yan Guo, Xue-Jun He, Yu-Zhuo Hou, Shu-Fang Zhu, Hong-Bin Cheng, Ying Nan, Zhen |
author_facet | Lin, Xiao-Yan Guo, Xue-Jun He, Yu-Zhuo Hou, Shu-Fang Zhu, Hong-Bin Cheng, Ying Nan, Zhen |
author_sort | Lin, Xiao-Yan |
collection | PubMed |
description | OBJECTIVE: Emerging evidence suggests that interleukin 37 (IL-37) plays an important role in the pathogenesis of several autoimmune diseases (ADs), but the correlations are still unclear. We conducted a meta-analysis to explore whether IL-37 gene (rs3811047) polymorphism was associated with susceptibility to multiple ADs in a Chinese population. METHODS: Relevant studies were searched in the PubMed, Embase, Chinese National Knowledge Infrastructure, and Chinese Wangfang databases up to August 31, 2017. Odds ratio (OR) and its 95% confidence interval (95% CI) was used to estimate the strength of the association in different genetic models. The results of fixed or random models were adopted according to the heterogeneity. Publication bias and sensitive analysis were also performed to evaluate the reliability of results. RESULTS: A total of 3161 patients and 4078 controls from 6 studies were included in this meta-analysis. Pooling all data together, a significant association between IL-37 gene (rs3811047 A/G) polymorphism and susceptibility to ADs in the Chinese population was found in all 4 genetic models (allelic model A vs G: OR = 0.73 95% CI = 0.67∼0.79; recessive model AA + AG vs GG: OR = 0.72, 95% CI = 0.65∼0.79; dominant model AA vs AG + GG: OR = 0.59, 95% CI = 0.45∼0.77; homozygous model AA vs GG: OR = 0.55, 95% CI = 0.42∼0.72). No heterogeneity and publication bias was detected in all models. Sensitive analysis indicated that all of the positive results are reliable. CONCLUSION: The IL- 37 (rs3811047) polymorphism contributes to the development of ADs in a Chinese population. |
format | Online Article Text |
id | pubmed-5908614 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-59086142018-04-30 Association between interleukin 37 (rs3811047) polymorphism and multiple autoimmune diseases in a Chinese population: A PRISMA-compliant meta-analysis Lin, Xiao-Yan Guo, Xue-Jun He, Yu-Zhuo Hou, Shu-Fang Zhu, Hong-Bin Cheng, Ying Nan, Zhen Medicine (Baltimore) 3500 OBJECTIVE: Emerging evidence suggests that interleukin 37 (IL-37) plays an important role in the pathogenesis of several autoimmune diseases (ADs), but the correlations are still unclear. We conducted a meta-analysis to explore whether IL-37 gene (rs3811047) polymorphism was associated with susceptibility to multiple ADs in a Chinese population. METHODS: Relevant studies were searched in the PubMed, Embase, Chinese National Knowledge Infrastructure, and Chinese Wangfang databases up to August 31, 2017. Odds ratio (OR) and its 95% confidence interval (95% CI) was used to estimate the strength of the association in different genetic models. The results of fixed or random models were adopted according to the heterogeneity. Publication bias and sensitive analysis were also performed to evaluate the reliability of results. RESULTS: A total of 3161 patients and 4078 controls from 6 studies were included in this meta-analysis. Pooling all data together, a significant association between IL-37 gene (rs3811047 A/G) polymorphism and susceptibility to ADs in the Chinese population was found in all 4 genetic models (allelic model A vs G: OR = 0.73 95% CI = 0.67∼0.79; recessive model AA + AG vs GG: OR = 0.72, 95% CI = 0.65∼0.79; dominant model AA vs AG + GG: OR = 0.59, 95% CI = 0.45∼0.77; homozygous model AA vs GG: OR = 0.55, 95% CI = 0.42∼0.72). No heterogeneity and publication bias was detected in all models. Sensitive analysis indicated that all of the positive results are reliable. CONCLUSION: The IL- 37 (rs3811047) polymorphism contributes to the development of ADs in a Chinese population. Wolters Kluwer Health 2018-04-13 /pmc/articles/PMC5908614/ /pubmed/29642198 http://dx.doi.org/10.1097/MD.0000000000010386 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 3500 Lin, Xiao-Yan Guo, Xue-Jun He, Yu-Zhuo Hou, Shu-Fang Zhu, Hong-Bin Cheng, Ying Nan, Zhen Association between interleukin 37 (rs3811047) polymorphism and multiple autoimmune diseases in a Chinese population: A PRISMA-compliant meta-analysis |
title | Association between interleukin 37 (rs3811047) polymorphism and multiple autoimmune diseases in a Chinese population: A PRISMA-compliant meta-analysis |
title_full | Association between interleukin 37 (rs3811047) polymorphism and multiple autoimmune diseases in a Chinese population: A PRISMA-compliant meta-analysis |
title_fullStr | Association between interleukin 37 (rs3811047) polymorphism and multiple autoimmune diseases in a Chinese population: A PRISMA-compliant meta-analysis |
title_full_unstemmed | Association between interleukin 37 (rs3811047) polymorphism and multiple autoimmune diseases in a Chinese population: A PRISMA-compliant meta-analysis |
title_short | Association between interleukin 37 (rs3811047) polymorphism and multiple autoimmune diseases in a Chinese population: A PRISMA-compliant meta-analysis |
title_sort | association between interleukin 37 (rs3811047) polymorphism and multiple autoimmune diseases in a chinese population: a prisma-compliant meta-analysis |
topic | 3500 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908614/ https://www.ncbi.nlm.nih.gov/pubmed/29642198 http://dx.doi.org/10.1097/MD.0000000000010386 |
work_keys_str_mv | AT linxiaoyan associationbetweeninterleukin37rs3811047polymorphismandmultipleautoimmunediseasesinachinesepopulationaprismacompliantmetaanalysis AT guoxuejun associationbetweeninterleukin37rs3811047polymorphismandmultipleautoimmunediseasesinachinesepopulationaprismacompliantmetaanalysis AT heyuzhuo associationbetweeninterleukin37rs3811047polymorphismandmultipleautoimmunediseasesinachinesepopulationaprismacompliantmetaanalysis AT houshufang associationbetweeninterleukin37rs3811047polymorphismandmultipleautoimmunediseasesinachinesepopulationaprismacompliantmetaanalysis AT zhuhongbin associationbetweeninterleukin37rs3811047polymorphismandmultipleautoimmunediseasesinachinesepopulationaprismacompliantmetaanalysis AT chengying associationbetweeninterleukin37rs3811047polymorphismandmultipleautoimmunediseasesinachinesepopulationaprismacompliantmetaanalysis AT nanzhen associationbetweeninterleukin37rs3811047polymorphismandmultipleautoimmunediseasesinachinesepopulationaprismacompliantmetaanalysis |