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The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome

The NLRP3 inflammasome has an important function in inflammation by promoting the processing of pro-IL-1β and pro-IL-18 to their mature bioactive forms, and by inducing cell death via pyroptosis. Here we show a critical function of the E3 ubiquitin ligase Pellino2 in facilitating activation of the N...

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Detalles Bibliográficos
Autores principales:	Humphries, Fiachra, Bergin, Ronan, Jackson, Ruaidhri, Delagic, Nezira, Wang, Bingwei, Yang, Shuo, Dubois, Alice V., Ingram, Rebecca J., Moynagh, Paul N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908787/ https://www.ncbi.nlm.nih.gov/pubmed/29674674 http://dx.doi.org/10.1038/s41467-018-03669-z

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