Cargando…
A proteomics landscape of circadian clock in mouse liver
As a circadian organ, liver executes diverse functions in different phase of the circadian clock. This process is believed to be driven by a transcription program. Here, we present a transcription factor (TF) DNA-binding activity-centered multi-dimensional proteomics landscape of the mouse liver, wh...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908788/ https://www.ncbi.nlm.nih.gov/pubmed/29674717 http://dx.doi.org/10.1038/s41467-018-03898-2 |
_version_ | 1783315762569543680 |
---|---|
author | Wang, Yunzhi Song, Lei Liu, Mingwei Ge, Rui Zhou, Quan Liu, Wanlin Li, Ruiyang Qie, Jingbo Zhen, Bei Wang, Yi He, Fuchu Qin, Jun Ding, Chen |
author_facet | Wang, Yunzhi Song, Lei Liu, Mingwei Ge, Rui Zhou, Quan Liu, Wanlin Li, Ruiyang Qie, Jingbo Zhen, Bei Wang, Yi He, Fuchu Qin, Jun Ding, Chen |
author_sort | Wang, Yunzhi |
collection | PubMed |
description | As a circadian organ, liver executes diverse functions in different phase of the circadian clock. This process is believed to be driven by a transcription program. Here, we present a transcription factor (TF) DNA-binding activity-centered multi-dimensional proteomics landscape of the mouse liver, which includes DNA-binding profiles of different TFs, phosphorylation, and ubiquitylation patterns, the nuclear sub-proteome, the whole proteome as well as the transcriptome, to portray the hierarchical circadian clock network of this tissue. The TF DNA-binding activity indicates diurnal oscillation in four major pathways, namely the immune response, glucose metabolism, fatty acid metabolism, and the cell cycle. We also isolate the mouse liver Kupffer cells and measure their proteomes during the circadian cycle to reveal a cell-type resolved circadian clock. These comprehensive data sets provide a rich data resource for the understanding of mouse hepatic physiology around the circadian clock. |
format | Online Article Text |
id | pubmed-5908788 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-59087882018-04-23 A proteomics landscape of circadian clock in mouse liver Wang, Yunzhi Song, Lei Liu, Mingwei Ge, Rui Zhou, Quan Liu, Wanlin Li, Ruiyang Qie, Jingbo Zhen, Bei Wang, Yi He, Fuchu Qin, Jun Ding, Chen Nat Commun Article As a circadian organ, liver executes diverse functions in different phase of the circadian clock. This process is believed to be driven by a transcription program. Here, we present a transcription factor (TF) DNA-binding activity-centered multi-dimensional proteomics landscape of the mouse liver, which includes DNA-binding profiles of different TFs, phosphorylation, and ubiquitylation patterns, the nuclear sub-proteome, the whole proteome as well as the transcriptome, to portray the hierarchical circadian clock network of this tissue. The TF DNA-binding activity indicates diurnal oscillation in four major pathways, namely the immune response, glucose metabolism, fatty acid metabolism, and the cell cycle. We also isolate the mouse liver Kupffer cells and measure their proteomes during the circadian cycle to reveal a cell-type resolved circadian clock. These comprehensive data sets provide a rich data resource for the understanding of mouse hepatic physiology around the circadian clock. Nature Publishing Group UK 2018-04-19 /pmc/articles/PMC5908788/ /pubmed/29674717 http://dx.doi.org/10.1038/s41467-018-03898-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Wang, Yunzhi Song, Lei Liu, Mingwei Ge, Rui Zhou, Quan Liu, Wanlin Li, Ruiyang Qie, Jingbo Zhen, Bei Wang, Yi He, Fuchu Qin, Jun Ding, Chen A proteomics landscape of circadian clock in mouse liver |
title | A proteomics landscape of circadian clock in mouse liver |
title_full | A proteomics landscape of circadian clock in mouse liver |
title_fullStr | A proteomics landscape of circadian clock in mouse liver |
title_full_unstemmed | A proteomics landscape of circadian clock in mouse liver |
title_short | A proteomics landscape of circadian clock in mouse liver |
title_sort | proteomics landscape of circadian clock in mouse liver |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908788/ https://www.ncbi.nlm.nih.gov/pubmed/29674717 http://dx.doi.org/10.1038/s41467-018-03898-2 |
work_keys_str_mv | AT wangyunzhi aproteomicslandscapeofcircadianclockinmouseliver AT songlei aproteomicslandscapeofcircadianclockinmouseliver AT liumingwei aproteomicslandscapeofcircadianclockinmouseliver AT gerui aproteomicslandscapeofcircadianclockinmouseliver AT zhouquan aproteomicslandscapeofcircadianclockinmouseliver AT liuwanlin aproteomicslandscapeofcircadianclockinmouseliver AT liruiyang aproteomicslandscapeofcircadianclockinmouseliver AT qiejingbo aproteomicslandscapeofcircadianclockinmouseliver AT zhenbei aproteomicslandscapeofcircadianclockinmouseliver AT wangyi aproteomicslandscapeofcircadianclockinmouseliver AT hefuchu aproteomicslandscapeofcircadianclockinmouseliver AT qinjun aproteomicslandscapeofcircadianclockinmouseliver AT dingchen aproteomicslandscapeofcircadianclockinmouseliver AT wangyunzhi proteomicslandscapeofcircadianclockinmouseliver AT songlei proteomicslandscapeofcircadianclockinmouseliver AT liumingwei proteomicslandscapeofcircadianclockinmouseliver AT gerui proteomicslandscapeofcircadianclockinmouseliver AT zhouquan proteomicslandscapeofcircadianclockinmouseliver AT liuwanlin proteomicslandscapeofcircadianclockinmouseliver AT liruiyang proteomicslandscapeofcircadianclockinmouseliver AT qiejingbo proteomicslandscapeofcircadianclockinmouseliver AT zhenbei proteomicslandscapeofcircadianclockinmouseliver AT wangyi proteomicslandscapeofcircadianclockinmouseliver AT hefuchu proteomicslandscapeofcircadianclockinmouseliver AT qinjun proteomicslandscapeofcircadianclockinmouseliver AT dingchen proteomicslandscapeofcircadianclockinmouseliver |