Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch

In acute cold stress in mammals, JMJD1A, a histone H3 lysine 9 (H3K9) demethylase, upregulates thermogenic gene expressions through β-adrenergic signaling in brown adipose tissue (BAT). Aside BAT-driven thermogenesis, mammals have another mechanism to cope with long-term cold stress by inducing the...

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Detalles Bibliográficos
Autores principales: Abe, Yohei, Fujiwara, Yosuke, Takahashi, Hiroki, Matsumura, Yoshihiro, Sawada, Tomonobu, Jiang, Shuying, Nakaki, Ryo, Uchida, Aoi, Nagao, Noriko, Naito, Makoto, Kajimura, Shingo, Kimura, Hiroshi, Osborne, Timothy F., Aburatani, Hiroyuki, Kodama, Tatsuhiko, Inagaki, Takeshi, Sakai, Juro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908789/
https://www.ncbi.nlm.nih.gov/pubmed/29674659
http://dx.doi.org/10.1038/s41467-018-03868-8

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