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Adjuvant immunotherapy for cancer: both dendritic cell-priming and check-point inhibitor blockade are required for immunotherapy

The immune system eliminates advanced cancer when treated with programmed cell death protein-1 (PD-1) or its ligand (PD-L1) blockade, but PD-1 therapy is effective in only ∼20% of patients with solid cancer. The PD-1 antibody mainly acts on the effector phase of cytotoxic T lymphocytes (CTLs) in tum...

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Detalles Bibliográficos
Autores principales: SEYA, Tsukasa, TAKEDA, Yohei, TAKASHIMA, Ken, YOSHIDA, Sumito, AZUMA, Masahiro, MATSUMOTO, Misako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Academy 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909060/
https://www.ncbi.nlm.nih.gov/pubmed/29526974
http://dx.doi.org/10.2183/pjab.94.011