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Variability in innate host immune responses to cryptococcosis
Cryptococcosis is an invasive fungal disease caused by Cryptococcus neoformans and the closely related species C. gattii. The severe form of the disease, cryptococcal meningitis (CM), is rapidly fatal without treatment. Although typically a disease of immunocompromised (especially HIV-positive) indi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Instituto Oswaldo Cruz, Ministério da Saúde
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909084/ https://www.ncbi.nlm.nih.gov/pubmed/29668826 http://dx.doi.org/10.1590/0074-02760180060 |
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author | Garelnabi, Mariam May, Robin C |
author_facet | Garelnabi, Mariam May, Robin C |
author_sort | Garelnabi, Mariam |
collection | PubMed |
description | Cryptococcosis is an invasive fungal disease caused by Cryptococcus neoformans and the closely related species C. gattii. The severe form of the disease, cryptococcal meningitis (CM), is rapidly fatal without treatment. Although typically a disease of immunocompromised (especially HIV-positive) individuals, there is growing awareness of cryptococcal disease amongst non-immunocompromised patients. Whilst substantial progress has been made in understanding the pathogenicity of C. neoformans in HIV patients, prospective data on cryptococcosis outside the context of HIV remains lacking. Below we review how innate immune responses vary between hosts depending on immunological status, and discuss risk factors and predictors of disease outcome in different groups. |
format | Online Article Text |
id | pubmed-5909084 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Instituto Oswaldo Cruz, Ministério da Saúde |
record_format | MEDLINE/PubMed |
spelling | pubmed-59090842018-04-24 Variability in innate host immune responses to cryptococcosis Garelnabi, Mariam May, Robin C Mem Inst Oswaldo Cruz Review Cryptococcosis is an invasive fungal disease caused by Cryptococcus neoformans and the closely related species C. gattii. The severe form of the disease, cryptococcal meningitis (CM), is rapidly fatal without treatment. Although typically a disease of immunocompromised (especially HIV-positive) individuals, there is growing awareness of cryptococcal disease amongst non-immunocompromised patients. Whilst substantial progress has been made in understanding the pathogenicity of C. neoformans in HIV patients, prospective data on cryptococcosis outside the context of HIV remains lacking. Below we review how innate immune responses vary between hosts depending on immunological status, and discuss risk factors and predictors of disease outcome in different groups. Instituto Oswaldo Cruz, Ministério da Saúde 2018-04-12 /pmc/articles/PMC5909084/ /pubmed/29668826 http://dx.doi.org/10.1590/0074-02760180060 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Garelnabi, Mariam May, Robin C Variability in innate host immune responses to cryptococcosis |
title | Variability in innate host immune responses to cryptococcosis |
title_full | Variability in innate host immune responses to cryptococcosis |
title_fullStr | Variability in innate host immune responses to cryptococcosis |
title_full_unstemmed | Variability in innate host immune responses to cryptococcosis |
title_short | Variability in innate host immune responses to cryptococcosis |
title_sort | variability in innate host immune responses to cryptococcosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909084/ https://www.ncbi.nlm.nih.gov/pubmed/29668826 http://dx.doi.org/10.1590/0074-02760180060 |
work_keys_str_mv | AT garelnabimariam variabilityininnatehostimmuneresponsestocryptococcosis AT mayrobinc variabilityininnatehostimmuneresponsestocryptococcosis |