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Cluster Headache: Epidemiology, Pathophysiology, Clinical Features, and Diagnosis
Cluster headache is a primary headache disorder affecting up to 0.1% of the population. Patients suffer from cluster headache attacks lasting from 15 to 180 min up to 8 times a day. The attacks are characterized by the severe unilateral pain mainly in the first division of the trigeminal nerve, with...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909131/ https://www.ncbi.nlm.nih.gov/pubmed/29720812 http://dx.doi.org/10.4103/aian.AIAN_349_17 |
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author | Wei, Diana Yi-Ting Yuan Ong, Jonathan Jia Goadsby, Peter James |
author_facet | Wei, Diana Yi-Ting Yuan Ong, Jonathan Jia Goadsby, Peter James |
author_sort | Wei, Diana Yi-Ting |
collection | PubMed |
description | Cluster headache is a primary headache disorder affecting up to 0.1% of the population. Patients suffer from cluster headache attacks lasting from 15 to 180 min up to 8 times a day. The attacks are characterized by the severe unilateral pain mainly in the first division of the trigeminal nerve, with associated prominent unilateral cranial autonomic symptoms and a sense of agitation and restlessness during the attacks. The male-to-female ratio is approximately 2.5:1. Experimental, clinical, and neuroimaging studies have advanced our understanding of the pathogenesis of cluster headache. The pathophysiology involves activation of the trigeminovascular complex and the trigeminal-autonomic reflex and accounts for the unilateral severe headache, the prominent ipsilateral cranial autonomic symptoms. In addition, the circadian and circannual rhythmicity unique to this condition is postulated to involve the hypothalamus and suprachiasmatic nucleus. Although the clinical features are distinct, it may be misdiagnosed, with patients often presenting to the otolaryngologist or dentist with symptoms. The prognosis of cluster headache remains difficult to predict. Patients with episodic cluster headache can shift to chronic cluster headache and vice versa. Longitudinally, cluster headache tends to remit with age with less frequent bouts and more prolonged periods of remission in between bouts. |
format | Online Article Text |
id | pubmed-5909131 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59091312018-05-02 Cluster Headache: Epidemiology, Pathophysiology, Clinical Features, and Diagnosis Wei, Diana Yi-Ting Yuan Ong, Jonathan Jia Goadsby, Peter James Ann Indian Acad Neurol Review Article Cluster headache is a primary headache disorder affecting up to 0.1% of the population. Patients suffer from cluster headache attacks lasting from 15 to 180 min up to 8 times a day. The attacks are characterized by the severe unilateral pain mainly in the first division of the trigeminal nerve, with associated prominent unilateral cranial autonomic symptoms and a sense of agitation and restlessness during the attacks. The male-to-female ratio is approximately 2.5:1. Experimental, clinical, and neuroimaging studies have advanced our understanding of the pathogenesis of cluster headache. The pathophysiology involves activation of the trigeminovascular complex and the trigeminal-autonomic reflex and accounts for the unilateral severe headache, the prominent ipsilateral cranial autonomic symptoms. In addition, the circadian and circannual rhythmicity unique to this condition is postulated to involve the hypothalamus and suprachiasmatic nucleus. Although the clinical features are distinct, it may be misdiagnosed, with patients often presenting to the otolaryngologist or dentist with symptoms. The prognosis of cluster headache remains difficult to predict. Patients with episodic cluster headache can shift to chronic cluster headache and vice versa. Longitudinally, cluster headache tends to remit with age with less frequent bouts and more prolonged periods of remission in between bouts. Medknow Publications & Media Pvt Ltd 2018-04 /pmc/articles/PMC5909131/ /pubmed/29720812 http://dx.doi.org/10.4103/aian.AIAN_349_17 Text en Copyright: © 2006 - 2018 Annals of Indian Academy of Neurology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Wei, Diana Yi-Ting Yuan Ong, Jonathan Jia Goadsby, Peter James Cluster Headache: Epidemiology, Pathophysiology, Clinical Features, and Diagnosis |
title | Cluster Headache: Epidemiology, Pathophysiology, Clinical Features, and Diagnosis |
title_full | Cluster Headache: Epidemiology, Pathophysiology, Clinical Features, and Diagnosis |
title_fullStr | Cluster Headache: Epidemiology, Pathophysiology, Clinical Features, and Diagnosis |
title_full_unstemmed | Cluster Headache: Epidemiology, Pathophysiology, Clinical Features, and Diagnosis |
title_short | Cluster Headache: Epidemiology, Pathophysiology, Clinical Features, and Diagnosis |
title_sort | cluster headache: epidemiology, pathophysiology, clinical features, and diagnosis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909131/ https://www.ncbi.nlm.nih.gov/pubmed/29720812 http://dx.doi.org/10.4103/aian.AIAN_349_17 |
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