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The spatio-temporal dynamics of deviance and target detection in the passive and active auditory oddball paradigm: a sLORETA study

BACKGROUND: Numerous studies have investigated the neural underpinnings of passive and active deviance and target detection in the well-known auditory oddball paradigm by means of event-related potentials (ERPs) or functional magnetic resonance imaging (fMRI). The present auditory oddball study inve...

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Autores principales: Justen, Christoph, Herbert, Cornelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909247/
https://www.ncbi.nlm.nih.gov/pubmed/29673322
http://dx.doi.org/10.1186/s12868-018-0422-3
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author Justen, Christoph
Herbert, Cornelia
author_facet Justen, Christoph
Herbert, Cornelia
author_sort Justen, Christoph
collection PubMed
description BACKGROUND: Numerous studies have investigated the neural underpinnings of passive and active deviance and target detection in the well-known auditory oddball paradigm by means of event-related potentials (ERPs) or functional magnetic resonance imaging (fMRI). The present auditory oddball study investigates the spatio-temporal dynamics of passive versus active deviance and target detection by analyzing amplitude modulations of early and late ERPs while at the same time exploring the neural sources underling this modulation with standardized low-resolution brain electromagnetic tomography (sLORETA) . METHODS: A 64-channel EEG was recorded from twelve healthy right-handed participants while listening to ‘standards’ and ‘deviants’ (500 vs. 1000 Hz pure tones) during a passive (block 1) and an active (block 2) listening condition. During passive listening, participants had to simply listen to the tones. During active listening they had to attend and press a key in response to the deviant tones. RESULTS: Passive and active listening elicited an N1 component, a mismatch negativity (MMN) as difference potential (whose amplitudes were temporally overlapping with the N1) and a P3 component. N1/MMN and P3 amplitudes were significantly more pronounced for deviants as compared to standards during both listening conditions. Active listening augmented P3 modulation to deviants significantly compared to passive listening, whereas deviance detection as indexed by N1/MMN modulation was unaffected by the task. During passive listening, sLORETA contrasts (deviants > standards) revealed significant activations in the right superior temporal gyrus (STG) and the lingual gyri bilaterally (N1/MMN) as well as in the left and right insulae (P3). During active listening, significant activations were found for the N1/MMN in the right inferior parietal lobule (IPL) and for the P3 in multiple cortical regions (e.g., precuneus). DISCUSSION: The results provide evidence for the hypothesis that passive as well as active deviance and target detection elicit cortical activations in spatially distributed brain regions and neural networks including the ventral attention network (VAN), dorsal attention network (DAN) and salience network (SN). Based on the temporal activation of the neural sources underlying ERP modulations, a neurophysiological model of passive and active deviance and target detection is proposed which can be tested in future studies.
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spelling pubmed-59092472018-04-30 The spatio-temporal dynamics of deviance and target detection in the passive and active auditory oddball paradigm: a sLORETA study Justen, Christoph Herbert, Cornelia BMC Neurosci Research Article BACKGROUND: Numerous studies have investigated the neural underpinnings of passive and active deviance and target detection in the well-known auditory oddball paradigm by means of event-related potentials (ERPs) or functional magnetic resonance imaging (fMRI). The present auditory oddball study investigates the spatio-temporal dynamics of passive versus active deviance and target detection by analyzing amplitude modulations of early and late ERPs while at the same time exploring the neural sources underling this modulation with standardized low-resolution brain electromagnetic tomography (sLORETA) . METHODS: A 64-channel EEG was recorded from twelve healthy right-handed participants while listening to ‘standards’ and ‘deviants’ (500 vs. 1000 Hz pure tones) during a passive (block 1) and an active (block 2) listening condition. During passive listening, participants had to simply listen to the tones. During active listening they had to attend and press a key in response to the deviant tones. RESULTS: Passive and active listening elicited an N1 component, a mismatch negativity (MMN) as difference potential (whose amplitudes were temporally overlapping with the N1) and a P3 component. N1/MMN and P3 amplitudes were significantly more pronounced for deviants as compared to standards during both listening conditions. Active listening augmented P3 modulation to deviants significantly compared to passive listening, whereas deviance detection as indexed by N1/MMN modulation was unaffected by the task. During passive listening, sLORETA contrasts (deviants > standards) revealed significant activations in the right superior temporal gyrus (STG) and the lingual gyri bilaterally (N1/MMN) as well as in the left and right insulae (P3). During active listening, significant activations were found for the N1/MMN in the right inferior parietal lobule (IPL) and for the P3 in multiple cortical regions (e.g., precuneus). DISCUSSION: The results provide evidence for the hypothesis that passive as well as active deviance and target detection elicit cortical activations in spatially distributed brain regions and neural networks including the ventral attention network (VAN), dorsal attention network (DAN) and salience network (SN). Based on the temporal activation of the neural sources underlying ERP modulations, a neurophysiological model of passive and active deviance and target detection is proposed which can be tested in future studies. BioMed Central 2018-04-19 /pmc/articles/PMC5909247/ /pubmed/29673322 http://dx.doi.org/10.1186/s12868-018-0422-3 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Justen, Christoph
Herbert, Cornelia
The spatio-temporal dynamics of deviance and target detection in the passive and active auditory oddball paradigm: a sLORETA study
title The spatio-temporal dynamics of deviance and target detection in the passive and active auditory oddball paradigm: a sLORETA study
title_full The spatio-temporal dynamics of deviance and target detection in the passive and active auditory oddball paradigm: a sLORETA study
title_fullStr The spatio-temporal dynamics of deviance and target detection in the passive and active auditory oddball paradigm: a sLORETA study
title_full_unstemmed The spatio-temporal dynamics of deviance and target detection in the passive and active auditory oddball paradigm: a sLORETA study
title_short The spatio-temporal dynamics of deviance and target detection in the passive and active auditory oddball paradigm: a sLORETA study
title_sort spatio-temporal dynamics of deviance and target detection in the passive and active auditory oddball paradigm: a sloreta study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909247/
https://www.ncbi.nlm.nih.gov/pubmed/29673322
http://dx.doi.org/10.1186/s12868-018-0422-3
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