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Incidence, pattern and prognosis of brain metastases in patients with metastatic triple negative breast cancer

BACKGROUND: To identify the incidence, recurrence pattern and prognosis of brain metastases (BM) among women with metastatic triple negative breast cancer (mTNBC) treated consecutively at a single institution during a 7-year period. METHODS: Patients with histologically confirmed mTNBC were retrospe...

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Autores principales: Jin, Jia, Gao, Yu, Zhang, Jian, Wang, Leiping, Wang, Biyun, Cao, Jun, Shao, Zhimin, Wang, Zhonghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909254/
https://www.ncbi.nlm.nih.gov/pubmed/29673325
http://dx.doi.org/10.1186/s12885-018-4371-0
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author Jin, Jia
Gao, Yu
Zhang, Jian
Wang, Leiping
Wang, Biyun
Cao, Jun
Shao, Zhimin
Wang, Zhonghua
author_facet Jin, Jia
Gao, Yu
Zhang, Jian
Wang, Leiping
Wang, Biyun
Cao, Jun
Shao, Zhimin
Wang, Zhonghua
author_sort Jin, Jia
collection PubMed
description BACKGROUND: To identify the incidence, recurrence pattern and prognosis of brain metastases (BM) among women with metastatic triple negative breast cancer (mTNBC) treated consecutively at a single institution during a 7-year period. METHODS: Patients with histologically confirmed mTNBC were retrospectively identified. The incidence of BM as first site of recurrence and the cumulative BM incidence were computed. We used the Cox proportional hazards model to identify the univariate and multivariate factors associated with survival. RESULTS: Four hundred thirty three patients were included with a median overall survival (OS) of 21.6 months after median follow-up for 48.1 months. BM was found in 29% (127/433) of the patients and about a quarter (32/127) of BM was first recurrence. The cumulative incidence of BM at 1 and 2 years was 17 and 25%, respectively. The median time from the diagnosis of extracranial metastases to BM was 10 months. Median OS following a diagnosis of BM was 7.3 months. The longer median OS from time of first recurrent BM was noted compared with those of subsequent recurrent (17.3 vs 6.3 months, p = 0.008). However, patients with first recurrent BM were associated with shorter OS compared with those without BM (17.3 vs 22.1 months, p = 0.006). The independent factors that increased BM death risk were > 3 brain lesions, no BM-directed treatment, subsequent recurrent BM, symptomatic BM and uncontrolled extracranial metastasis. CONCLUSIONS: Patients with mTNBC have a high incidence of early BM with subsequent poor survival. The findings lend support to consideration of screening imaging of the brain for mTNBC patients.
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spelling pubmed-59092542018-04-30 Incidence, pattern and prognosis of brain metastases in patients with metastatic triple negative breast cancer Jin, Jia Gao, Yu Zhang, Jian Wang, Leiping Wang, Biyun Cao, Jun Shao, Zhimin Wang, Zhonghua BMC Cancer Research Article BACKGROUND: To identify the incidence, recurrence pattern and prognosis of brain metastases (BM) among women with metastatic triple negative breast cancer (mTNBC) treated consecutively at a single institution during a 7-year period. METHODS: Patients with histologically confirmed mTNBC were retrospectively identified. The incidence of BM as first site of recurrence and the cumulative BM incidence were computed. We used the Cox proportional hazards model to identify the univariate and multivariate factors associated with survival. RESULTS: Four hundred thirty three patients were included with a median overall survival (OS) of 21.6 months after median follow-up for 48.1 months. BM was found in 29% (127/433) of the patients and about a quarter (32/127) of BM was first recurrence. The cumulative incidence of BM at 1 and 2 years was 17 and 25%, respectively. The median time from the diagnosis of extracranial metastases to BM was 10 months. Median OS following a diagnosis of BM was 7.3 months. The longer median OS from time of first recurrent BM was noted compared with those of subsequent recurrent (17.3 vs 6.3 months, p = 0.008). However, patients with first recurrent BM were associated with shorter OS compared with those without BM (17.3 vs 22.1 months, p = 0.006). The independent factors that increased BM death risk were > 3 brain lesions, no BM-directed treatment, subsequent recurrent BM, symptomatic BM and uncontrolled extracranial metastasis. CONCLUSIONS: Patients with mTNBC have a high incidence of early BM with subsequent poor survival. The findings lend support to consideration of screening imaging of the brain for mTNBC patients. BioMed Central 2018-04-19 /pmc/articles/PMC5909254/ /pubmed/29673325 http://dx.doi.org/10.1186/s12885-018-4371-0 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Jin, Jia
Gao, Yu
Zhang, Jian
Wang, Leiping
Wang, Biyun
Cao, Jun
Shao, Zhimin
Wang, Zhonghua
Incidence, pattern and prognosis of brain metastases in patients with metastatic triple negative breast cancer
title Incidence, pattern and prognosis of brain metastases in patients with metastatic triple negative breast cancer
title_full Incidence, pattern and prognosis of brain metastases in patients with metastatic triple negative breast cancer
title_fullStr Incidence, pattern and prognosis of brain metastases in patients with metastatic triple negative breast cancer
title_full_unstemmed Incidence, pattern and prognosis of brain metastases in patients with metastatic triple negative breast cancer
title_short Incidence, pattern and prognosis of brain metastases in patients with metastatic triple negative breast cancer
title_sort incidence, pattern and prognosis of brain metastases in patients with metastatic triple negative breast cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909254/
https://www.ncbi.nlm.nih.gov/pubmed/29673325
http://dx.doi.org/10.1186/s12885-018-4371-0
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