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Investigation into cardiac sympathetic innervation during the commencement of haemodialysis in patients with chronic kidney disease
BACKGROUND: Patients with chronic kidney disease (CKD) who undergo chronic haemodialysis (HD) show altered sympathetic tone, which is related to a higher cardiovascular mortality. The purpose of this study was to investigate the effect of transition from pre-HD to HD on cardiac sympathetic innervati...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer International Publishing
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909356/ https://www.ncbi.nlm.nih.gov/pubmed/29708199 http://dx.doi.org/10.1186/s41747-017-0027-0 |
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author | Noordzij, Walter Özyilmaz, Akin Glaudemans, Andor W. J. M. Tio, René A. Goet, Esther R. Franssen, Casper F. M. Slart, Riemer H. J. A. |
author_facet | Noordzij, Walter Özyilmaz, Akin Glaudemans, Andor W. J. M. Tio, René A. Goet, Esther R. Franssen, Casper F. M. Slart, Riemer H. J. A. |
author_sort | Noordzij, Walter |
collection | PubMed |
description | BACKGROUND: Patients with chronic kidney disease (CKD) who undergo chronic haemodialysis (HD) show altered sympathetic tone, which is related to a higher cardiovascular mortality. The purpose of this study was to investigate the effect of transition from pre-HD to HD on cardiac sympathetic innervation. METHODS: Eighteen patients aged 58 ± 18 years (mean ± standard deviation [SD]), 13 males and five females, with stage 5 CKD and nine healthy control subjects aged 52 ± 17 (mean ± SD), three males and six females, were included in this prospective study between May 2010 and December 2013. All patients underwent (123)I-labelled meta-iodobenzylguanidine ((123)I-MIBG) scintigraphy for cardiac sympathetic innervation and electrocardiographically gated adenosine stress and rest (99m)Tc-labelled tetrofosmin single-photon emission computed tomography for myocardial perfusion imaging prior to (pre-HD) and 6 months after the start of HD. Results of (123)I-MIBG scans in patients were compared to controls. Impaired cardiac sympathetic innervation was defined as late heart-to-mediastinum ratio (HMR) < 2.0. RESULTS: Mean late HMR was lower in patients during HD (2.3) than in controls (2.9) (p = 0.035); however, in patients it did not differ between pre-HD and after the start of HD. During HD, two patients showed new sympathetic innervation abnormalities, and in three patients innervation abnormalities seemed to coincide with myocardial perfusion abnormalities. CONCLUSIONS: CKD patients show cardiac sympathetic innervation abnormalities, which do not seem to progress during the maintenance HD. The relationship between sympathetic innervation abnormalities and myocardial perfusion abnormalities in HD patients needs further exploration. |
format | Online Article Text |
id | pubmed-5909356 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-59093562018-04-24 Investigation into cardiac sympathetic innervation during the commencement of haemodialysis in patients with chronic kidney disease Noordzij, Walter Özyilmaz, Akin Glaudemans, Andor W. J. M. Tio, René A. Goet, Esther R. Franssen, Casper F. M. Slart, Riemer H. J. A. Eur Radiol Exp Original Article BACKGROUND: Patients with chronic kidney disease (CKD) who undergo chronic haemodialysis (HD) show altered sympathetic tone, which is related to a higher cardiovascular mortality. The purpose of this study was to investigate the effect of transition from pre-HD to HD on cardiac sympathetic innervation. METHODS: Eighteen patients aged 58 ± 18 years (mean ± standard deviation [SD]), 13 males and five females, with stage 5 CKD and nine healthy control subjects aged 52 ± 17 (mean ± SD), three males and six females, were included in this prospective study between May 2010 and December 2013. All patients underwent (123)I-labelled meta-iodobenzylguanidine ((123)I-MIBG) scintigraphy for cardiac sympathetic innervation and electrocardiographically gated adenosine stress and rest (99m)Tc-labelled tetrofosmin single-photon emission computed tomography for myocardial perfusion imaging prior to (pre-HD) and 6 months after the start of HD. Results of (123)I-MIBG scans in patients were compared to controls. Impaired cardiac sympathetic innervation was defined as late heart-to-mediastinum ratio (HMR) < 2.0. RESULTS: Mean late HMR was lower in patients during HD (2.3) than in controls (2.9) (p = 0.035); however, in patients it did not differ between pre-HD and after the start of HD. During HD, two patients showed new sympathetic innervation abnormalities, and in three patients innervation abnormalities seemed to coincide with myocardial perfusion abnormalities. CONCLUSIONS: CKD patients show cardiac sympathetic innervation abnormalities, which do not seem to progress during the maintenance HD. The relationship between sympathetic innervation abnormalities and myocardial perfusion abnormalities in HD patients needs further exploration. Springer International Publishing 2017-12-06 /pmc/articles/PMC5909356/ /pubmed/29708199 http://dx.doi.org/10.1186/s41747-017-0027-0 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Noordzij, Walter Özyilmaz, Akin Glaudemans, Andor W. J. M. Tio, René A. Goet, Esther R. Franssen, Casper F. M. Slart, Riemer H. J. A. Investigation into cardiac sympathetic innervation during the commencement of haemodialysis in patients with chronic kidney disease |
title | Investigation into cardiac sympathetic innervation during the commencement of haemodialysis in patients with chronic kidney disease |
title_full | Investigation into cardiac sympathetic innervation during the commencement of haemodialysis in patients with chronic kidney disease |
title_fullStr | Investigation into cardiac sympathetic innervation during the commencement of haemodialysis in patients with chronic kidney disease |
title_full_unstemmed | Investigation into cardiac sympathetic innervation during the commencement of haemodialysis in patients with chronic kidney disease |
title_short | Investigation into cardiac sympathetic innervation during the commencement of haemodialysis in patients with chronic kidney disease |
title_sort | investigation into cardiac sympathetic innervation during the commencement of haemodialysis in patients with chronic kidney disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909356/ https://www.ncbi.nlm.nih.gov/pubmed/29708199 http://dx.doi.org/10.1186/s41747-017-0027-0 |
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