Cargando…

Upregulation of Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Mediates the Reversal Effect of Verapamil on Chemo-Resistance to Adriamycin of Hepatocellular Carcinoma

BACKGROUND: The aim of this study was to investigate the role of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) in the reversal effect of verapamil (VER) on chemo-resistance to Adriamycin (ADM) in treatment of hepatocellular carcinoma (HCC). MATERIAL/METHODS: HCC cell lines SMMC-7721 and BEL-7402...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Guangshan, Fan, Gaofei, Zhang, Tengyue, Ma, Kelong, Huang, Jin, Liu, Miao, Teng, Xiaolu, Xu, Kun, Fan, Pingsheng, Cheng, Dongmiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Scientific Literature, Inc. 2018
Materias:	Lab/In Vitro Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909418/ https://www.ncbi.nlm.nih.gov/pubmed/29627846 http://dx.doi.org/10.12659/MSM.908925

Ejemplares similares

CDKN2B is critical for verapamil-mediated reversal of doxorubicin resistance in hepatocellular carcinoma
por: Zhang, Tengyue, et al.
Publicado: (2017)

Overexpression of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) in boys with cryptorchidism
por: Toliczenko-Bernatowicz, Dorota, et al.
Publicado: (2018)

Clinical evaluation of targeted arterial perfusion of verapamil and chemotherapeutic drugs in interventional therapy of advanced lung cancer
por: Huang, Jin, et al.
Publicado: (2013)

Pivotal Role of Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) in Uterine Leiomyoma
por: Suzuki, Tomoo, et al.
Publicado: (2023)

Inhibition of Siah2 Ubiquitin Ligase by Vitamin K3 Attenuates Chronic Myeloid Leukemia Chemo-Resistance in Hypoxic Microenvironment
por: Huang, Jixian, et al.
Publicado: (2018)

Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo
por: Zhang, Mingming, et al.
Publicado: (2014)

GTS-21 Promotes α7 nAChR to Alleviate Intestinal Ischemia-Reperfusion-Induced Apoptosis and Inflammation of Enterocytes
por: Wang, Haisong, et al.
Publicado: (2020)

Rosmarinic Acid Combined with Adriamycin Induces Apoptosis by Triggering Mitochondria-Mediated Signaling Pathway in HepG2 and Bel-7402 Cells
por: Huang, Youxia, et al.
Publicado: (2018)

MiR-34b-3p Represses the Multidrug-Chemoresistance of Bladder Cancer Cells by Regulating the CCND2 and P2RY1 Genes
por: Tan, Yiao, et al.
Publicado: (2019)

Ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) is a potential tumour suppressor in prostate cancer and is frequently silenced by promoter methylation
por: Ummanni, Ramesh, et al.
Publicado: (2011)

Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Promotes Uterine Serous Cancer Cell Proliferation and Cell Cycle Progression
por: Kwan, Suet-Ying, et al.
Publicado: (2020)

High Expression of MUC15 Is Correlated with Poor Prognosis of Pancreatic Cancer and Promotes Migration, Invasion, and Chemo-Resistance In Vitro
por: Wang, Shunda, et al.
Publicado: (2020)

Transmembrane and Ubiquitin-Like Domain Containing 1 Protein (TMUB1) Negatively Regulates Hepatocellular Carcinoma Proliferation via Regulating Signal Transducer and Activator of Transcription 1 (STAT1)
por: Chen, Yin, et al.
Publicado: (2019)

Downregulation of MACC1 facilitates the reversal effect of verapamil on the chemoresistance to active metabolite of irinotecan in human colon cancer cells
por: Qian, Xiaotao, et al.
Publicado: (2022)

Knockdown of Ubiquitin Associated Protein 2-Like (UBAP2L) Inhibits Growth and Metastasis of Hepatocellular Carcinoma
por: Li, Qian, et al.
Publicado: (2018)

Overexpression of the Ubiquitin-Specific Peptidase 9 X-Linked (USP9X) Gene is Associated with Upregulation of Cyclin D1 (CCND1) and Downregulation of Cyclin-Dependent Inhibitor Kinase 1A (CDKN1A) in Breast Cancer Tissue and Cell Lines
por: Li, Hang, et al.
Publicado: (2019)

Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimer's disease
por: Zetterberg, Madeleine, et al.
Publicado: (2010)

Forkhead Box Protein J1 (FOXJ1) is Overexpressed in Colorectal Cancer and Promotes Nuclear Translocation of β-Catenin in SW620 Cells
por: Liu, Kuiliang, et al.
Publicado: (2017)

Collagen Type X Alpha 1 (COL10A1) Contributes to Cell Proliferation, Migration, and Invasion by Targeting Prolyl 4-Hydroxylase Beta Polypeptide (P4HB) in Breast Cancer
por: Yang, Weibin, et al.
Publicado: (2021)

Small Nucleolar RNA Host Gene 12 (SNHG12) Promotes Proliferation and Invasion of Laryngeal Cancer Cells via Sponging miR-129-5p and Potentiating WW Domain-Containing E3 Ubiquitin Protein Ligase 1 (WWP1) Expression
por: Li, Jing, et al.
Publicado: (2019)

Knockdown of MON1B Exerts Anti-Tumor Effects in Colon Cancer In Vitro
por: Jiang, Lai, et al.
Publicado: (2018)

Tripartite Motif Containing 52 Positively Regulates NF-κB Signaling by Promoting IκBα Ubiquitination in Lipopolysaccharide-Treated Microglial Cell Activation
por: Zhang, Pei, et al.
Publicado: (2020)

Ras GTPase-Activating-Like Protein IQGAP1 (IQGAP1) Promotes Breast Cancer Proliferation and Invasion and Correlates with Poor Clinical Outcomes
por: Zeng, Fanye, et al.
Publicado: (2018)

Orai1 Promotes Osteosarcoma Metastasis by Activating the Ras-Rac1-WAVE2 Signaling Pathway
por: Guo, Yunshan, et al.
Publicado: (2019)

Ginsenoside Rb1 Facilitates Browning by Repressing Wnt/β-Catenin Signaling in 3T3-L1 Adipocytes
por: Fan, Qingxin, et al.
Publicado: (2021)

PTEN-Induced Putative Kinase 1 (PINK1)/Parkin-Mediated Mitophagy Protects PC12 Cells Against Cisplatin-Induced Neurotoxicity
por: Zhang, Yao, et al.
Publicado: (2019)

Long Non-Coding RNAs (lncRNAs) Tumor-Suppressive Role of lncRNA on Chromosome 8p12 (TSLNC8) Inhibits Tumor Metastasis and Promotes Apoptosis by Regulating Interleukin 6 (IL-6)/Signal Transducer and Activator of Transcription 3 (STAT3)/Hypoxia-Inducible Factor 1-alpha (HIF-1α) Signaling Pathway in Non-Small Cell Lung Cancer
por: Fan, Hanli, et al.
Publicado: (2019)

Loss of Speckle-Type POZ Protein Promotes Prostate Cancer Cell Migration and Invasion Through Upregulation of MCP-1
por: Shi, Junlin, et al.
Publicado: (2021)

Myoglobin Mediates Autophagy of NRK-52E in Rat Renal Tubular Epithelial Cells Via the Pink1/Parkin Signaling Pathway
por: Chen, Zhiguo, et al.
Publicado: (2020)

Effects of Shock Waves on Expression of IL-6, IL-8, MCP-1, and TNF-α Expression by Human Periodontal Ligament Fibroblasts: An In Vitro Study
por: Cai, Zhiyu, et al.
Publicado: (2016)

Percutaneous Endoscopic Lumbar Discectomy (PELD) via a Transforaminal and Interlaminar Combined Approach for Very Highly Migrated Lumbar Disc Herniation (LDH) Between L4/5 and L5/S1 Level
por: Zhao, Yongzhao, et al.
Publicado: (2020)

Inhibition of Hydrogen Peroxide-Induced Human Umbilical Vein Endothelial Cells Aging by Allicin Depends on Sirtuin1 Activation
por: Lin, Xiao-Long, et al.
Publicado: (2017)

Apigenin Mitigates Intervertebral Disc Degeneration through the Amelioration of Tumor Necrosis Factor α (TNF-α) Signaling Pathway
por: Ding, Fan, et al.
Publicado: (2020)

Overexpression of Linc 4930556M19Rik Suppresses High Glucose-Triggered Podocyte Apoptosis, Fibrosis and Inflammation via the miR-27a-3p/Metalloproteinase 3 (TIMP3) Axis in Diabetic Nephropathy
por: Fan, Hong, et al.
Publicado: (2020)

Highly Expressed Granulocyte Colony-Stimulating Factor (G-CSF) and Granulocyte Colony-Stimulating Factor Receptor (G-CSFR) in Human Gastric Cancer Leads to Poor Survival
por: Fan, Zhisong, et al.
Publicado: (2018)

Knockdown of Phospholipase Cɛ (PLCɛ) Inhibits Cell Proliferation via Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN)/AKT Signaling Pathway in Human Prostate Cancer
por: Wang, Xiao, et al.
Publicado: (2018)

Octreotide-Paclitaxel Conjugate Reverses Paclitaxel Resistance by p38 Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway in A2780/Taxol Human Ovarian Cancer Cells
por: Fan, Li-li, et al.
Publicado: (2020)

Identification of Differentially Expressed Genes in Pelvic Organ Prolapse by RNA-Seq
por: Xie, Ruoyun, et al.
Publicado: (2016)

Protective Effects of Sinomenine on CFA-Induced Inflammatory Pain in Rats
por: Yuan, Yan, et al.
Publicado: (2018)

P2X7 Receptor (P2X7R) of Microglia Mediates Neuroinflammation by Regulating (NOD)-Like Receptor Protein 3 (NLRP3) Inflammasome-Dependent Inflammation After Spinal Cord Injury
por: Fan, Xiao, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_hbd98u15mqs2mfm8n58696gd3d