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An interplay of miRNA abundance and target site architecture determines miRNA activity and specificity
MicroRNAs often occur in families whose members share an identical 5′ terminal ‘seed’ sequence. The seed is a major determinant of miRNA activity, and family members are thought to act redundantly on target mRNAs with perfect seed matches, i.e. sequences complementary to the seed. However, recently...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909448/ https://www.ncbi.nlm.nih.gov/pubmed/29897601 http://dx.doi.org/10.1093/nar/gky201 |