Ammonium and arsenic trioxide are potent facilitators of oligonucleotide function when delivered by gymnosis

Oligonucleotide (ON) concentrations employed for therapeutic applications vary widely, but in general are high enough to raise significant concerns for off target effects and cellular toxicity. However, lowering ON concentrations reduces the chances of a therapeutic response, since typically relativ...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaowei, Castanotto, Daniela, Liu, Xueli, Shemi, Amotz, Stein, Cy A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909461/
https://www.ncbi.nlm.nih.gov/pubmed/29522198
http://dx.doi.org/10.1093/nar/gky150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909461/
https://www.ncbi.nlm.nih.gov/pubmed/29522198
http://dx.doi.org/10.1093/nar/gky150

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