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Ammonium and arsenic trioxide are potent facilitators of oligonucleotide function when delivered by gymnosis
Oligonucleotide (ON) concentrations employed for therapeutic applications vary widely, but in general are high enough to raise significant concerns for off target effects and cellular toxicity. However, lowering ON concentrations reduces the chances of a therapeutic response, since typically relativ...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909461/ https://www.ncbi.nlm.nih.gov/pubmed/29522198 http://dx.doi.org/10.1093/nar/gky150 |