S-phase Specific Downregulation of Human O(6)-Methylguanine DNA Methyltransferase (MGMT) and its Serendipitous Interactions with PCNA and p21(cip1) Proteins in Glioma Cells

Whether the antimutagenic DNA repair protein MGMT works solo in human cells and if it has other cellular functions is not known. Here, we show that human MGMT associates with PCNA and in turn, with the cell cycle inhibitor, p21(cip1) in glioblastoma and other cancer cell lines. MGMT protein was show...

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Detalles Bibliográficos
Autores principales: Mostofa, AGM, Punganuru, Surendra R., Madala, Hanumantha Rao, Srivenugopal, Kalkunte S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2018
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909491/
https://www.ncbi.nlm.nih.gov/pubmed/29510343
http://dx.doi.org/10.1016/j.neo.2018.01.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909491/
https://www.ncbi.nlm.nih.gov/pubmed/29510343
http://dx.doi.org/10.1016/j.neo.2018.01.010

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