Cargando…
Shear wave elastography predicts hepatocellular carcinoma risk in hepatitis C patients after sustained virological response
AIM: To evaluate the relationship between fibrosis and HCC after sustained virological response (SVR) to treatment for chronic hepatitis C (HCV). METHODS: This single-center study retrospectively evaluated 196 patients who achieved SVR after HCV infection. The associations of risk factors with HCC d...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909618/ https://www.ncbi.nlm.nih.gov/pubmed/29672518 http://dx.doi.org/10.1371/journal.pone.0195173 |
_version_ | 1783315935644352512 |
---|---|
author | Hamada, Koichi Saitoh, Satoshi Nishino, Noriyuki Fukushima, Daizo Horikawa, Yoshinori Nishida, Shinya Honda, Michitaka |
author_facet | Hamada, Koichi Saitoh, Satoshi Nishino, Noriyuki Fukushima, Daizo Horikawa, Yoshinori Nishida, Shinya Honda, Michitaka |
author_sort | Hamada, Koichi |
collection | PubMed |
description | AIM: To evaluate the relationship between fibrosis and HCC after sustained virological response (SVR) to treatment for chronic hepatitis C (HCV). METHODS: This single-center study retrospectively evaluated 196 patients who achieved SVR after HCV infection. The associations of risk factors with HCC development after HCV eradication were evaluated using univariate and multivariate Cox proportional hazards regression models. RESULTS: Among the 196 patients, 8 patients (4.1%) developed HCC after SVR during a median follow-up of 26 months. Multivariate analyses revealed that HCC development was independently associated with age of ≥75 years (risk ratio [RR] = 35.16), α- fetoprotein levels of ≥6 ng/mL (RR = 40.30), and SWE results of ≥11 kPa (RR = 28.71). CONCLUSIONS: Our findings indicate that SWE may facilitate HCC surveillance after SVR and the identification of patients who have an increased risk of HCC after HCV clearance. |
format | Online Article Text |
id | pubmed-5909618 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-59096182018-05-04 Shear wave elastography predicts hepatocellular carcinoma risk in hepatitis C patients after sustained virological response Hamada, Koichi Saitoh, Satoshi Nishino, Noriyuki Fukushima, Daizo Horikawa, Yoshinori Nishida, Shinya Honda, Michitaka PLoS One Research Article AIM: To evaluate the relationship between fibrosis and HCC after sustained virological response (SVR) to treatment for chronic hepatitis C (HCV). METHODS: This single-center study retrospectively evaluated 196 patients who achieved SVR after HCV infection. The associations of risk factors with HCC development after HCV eradication were evaluated using univariate and multivariate Cox proportional hazards regression models. RESULTS: Among the 196 patients, 8 patients (4.1%) developed HCC after SVR during a median follow-up of 26 months. Multivariate analyses revealed that HCC development was independently associated with age of ≥75 years (risk ratio [RR] = 35.16), α- fetoprotein levels of ≥6 ng/mL (RR = 40.30), and SWE results of ≥11 kPa (RR = 28.71). CONCLUSIONS: Our findings indicate that SWE may facilitate HCC surveillance after SVR and the identification of patients who have an increased risk of HCC after HCV clearance. Public Library of Science 2018-04-19 /pmc/articles/PMC5909618/ /pubmed/29672518 http://dx.doi.org/10.1371/journal.pone.0195173 Text en © 2018 Hamada et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Hamada, Koichi Saitoh, Satoshi Nishino, Noriyuki Fukushima, Daizo Horikawa, Yoshinori Nishida, Shinya Honda, Michitaka Shear wave elastography predicts hepatocellular carcinoma risk in hepatitis C patients after sustained virological response |
title | Shear wave elastography predicts hepatocellular carcinoma risk in hepatitis C patients after sustained virological response |
title_full | Shear wave elastography predicts hepatocellular carcinoma risk in hepatitis C patients after sustained virological response |
title_fullStr | Shear wave elastography predicts hepatocellular carcinoma risk in hepatitis C patients after sustained virological response |
title_full_unstemmed | Shear wave elastography predicts hepatocellular carcinoma risk in hepatitis C patients after sustained virological response |
title_short | Shear wave elastography predicts hepatocellular carcinoma risk in hepatitis C patients after sustained virological response |
title_sort | shear wave elastography predicts hepatocellular carcinoma risk in hepatitis c patients after sustained virological response |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909618/ https://www.ncbi.nlm.nih.gov/pubmed/29672518 http://dx.doi.org/10.1371/journal.pone.0195173 |
work_keys_str_mv | AT hamadakoichi shearwaveelastographypredictshepatocellularcarcinomariskinhepatitiscpatientsaftersustainedvirologicalresponse AT saitohsatoshi shearwaveelastographypredictshepatocellularcarcinomariskinhepatitiscpatientsaftersustainedvirologicalresponse AT nishinonoriyuki shearwaveelastographypredictshepatocellularcarcinomariskinhepatitiscpatientsaftersustainedvirologicalresponse AT fukushimadaizo shearwaveelastographypredictshepatocellularcarcinomariskinhepatitiscpatientsaftersustainedvirologicalresponse AT horikawayoshinori shearwaveelastographypredictshepatocellularcarcinomariskinhepatitiscpatientsaftersustainedvirologicalresponse AT nishidashinya shearwaveelastographypredictshepatocellularcarcinomariskinhepatitiscpatientsaftersustainedvirologicalresponse AT hondamichitaka shearwaveelastographypredictshepatocellularcarcinomariskinhepatitiscpatientsaftersustainedvirologicalresponse |