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Slit–Robo signalling in heart development

The Slit ligands and their Robo receptors are well-known for their roles during axon guidance in the central nervous system but are still relatively unknown in the cardiac field. However, data from different animal models suggest a broad involvement of the pathway in many aspects of heart developmen...

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Autores principales: Zhao, Juanjuan, Mommersteeg, Mathilda T M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909645/
https://www.ncbi.nlm.nih.gov/pubmed/29538649
http://dx.doi.org/10.1093/cvr/cvy061
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author Zhao, Juanjuan
Mommersteeg, Mathilda T M
author_facet Zhao, Juanjuan
Mommersteeg, Mathilda T M
author_sort Zhao, Juanjuan
collection PubMed
description The Slit ligands and their Robo receptors are well-known for their roles during axon guidance in the central nervous system but are still relatively unknown in the cardiac field. However, data from different animal models suggest a broad involvement of the pathway in many aspects of heart development, from cardiac cell migration and alignment, lumen formation, chamber formation, to the formation of the ventricular septum, semilunar and atrioventricular valves, caval veins, and pericardium. Absence of one or more of the genes in the pathway results in defects ranging from bicuspid aortic valves to ventricular septal defects and abnormal venous connections to the heart. Congenital heart defects are the most common congenital malformations found in life new-born babies and progress in methods for large scale human genetic testing has significantly enhanced the identification of new causative genes involved in human congenital heart disease. Recently, loss of function variants in ROBO1 have also been linked to ventricular septal defects and tetralogy of Fallot in patients. Here, we will give an overview of the role of the Slit–Robo signalling pathway in Drosophila, zebrafish, and mouse heart development. The extent of these data warrant further attention on the SLIT–ROBO signalling pathway as a candidate for an array of human congenital heart defects.
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spelling pubmed-59096452018-04-24 Slit–Robo signalling in heart development Zhao, Juanjuan Mommersteeg, Mathilda T M Cardiovasc Res Reviews The Slit ligands and their Robo receptors are well-known for their roles during axon guidance in the central nervous system but are still relatively unknown in the cardiac field. However, data from different animal models suggest a broad involvement of the pathway in many aspects of heart development, from cardiac cell migration and alignment, lumen formation, chamber formation, to the formation of the ventricular septum, semilunar and atrioventricular valves, caval veins, and pericardium. Absence of one or more of the genes in the pathway results in defects ranging from bicuspid aortic valves to ventricular septal defects and abnormal venous connections to the heart. Congenital heart defects are the most common congenital malformations found in life new-born babies and progress in methods for large scale human genetic testing has significantly enhanced the identification of new causative genes involved in human congenital heart disease. Recently, loss of function variants in ROBO1 have also been linked to ventricular septal defects and tetralogy of Fallot in patients. Here, we will give an overview of the role of the Slit–Robo signalling pathway in Drosophila, zebrafish, and mouse heart development. The extent of these data warrant further attention on the SLIT–ROBO signalling pathway as a candidate for an array of human congenital heart defects. Oxford University Press 2018-05-01 2018-03-10 /pmc/articles/PMC5909645/ /pubmed/29538649 http://dx.doi.org/10.1093/cvr/cvy061 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of the European Society of Cardiology. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Zhao, Juanjuan
Mommersteeg, Mathilda T M
Slit–Robo signalling in heart development
title Slit–Robo signalling in heart development
title_full Slit–Robo signalling in heart development
title_fullStr Slit–Robo signalling in heart development
title_full_unstemmed Slit–Robo signalling in heart development
title_short Slit–Robo signalling in heart development
title_sort slit–robo signalling in heart development
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909645/
https://www.ncbi.nlm.nih.gov/pubmed/29538649
http://dx.doi.org/10.1093/cvr/cvy061
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