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Overexpression of HDAC9 is associated with poor prognosis and tumor progression of breast cancer in Chinese females
BACKGROUND: Breast cancer represents a serious health issue among females. HDAC9 has been identified as an oncogene in human cancers. This study sought to assess the prognostic value and the biologic function of HDAC9 in breast cancer patients. METHODS: Expression of HDAC9 in breast cancer tissues a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909784/ https://www.ncbi.nlm.nih.gov/pubmed/29713186 http://dx.doi.org/10.2147/OTT.S164583 |
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author | Huang, Yixiang Jian, Wei Zhao, Junyong Wang, Gang |
author_facet | Huang, Yixiang Jian, Wei Zhao, Junyong Wang, Gang |
author_sort | Huang, Yixiang |
collection | PubMed |
description | BACKGROUND: Breast cancer represents a serious health issue among females. HDAC9 has been identified as an oncogene in human cancers. This study sought to assess the prognostic value and the biologic function of HDAC9 in breast cancer patients. METHODS: Expression of HDAC9 in breast cancer tissues and cells was evaluated by quantitative real-time polymerase chain reaction. Kaplan–Meier survival analysis and Cox regression assay were conducted to explore the prognostic significance of HDAC9. Cell experiments were performed to investigate the effects of HDAC9 on the biologic behaviors of breast cancer cells. RESULTS: Expression of HDAC9 was significantly upregulated in both cancerous tissues and cells compared with the normal controls (all P<0.05). Overexpression of HDAC9 was correlated with lymph node metastasis (P=0.021) and TNM stage (P=0.004). Patients with high HDAC9 had poor overall survival compared to those with low levels of HDAC9 (log-rank P<0.05). Elevated HDAC9 was found to be an independent prognostic factor for the patients (hazard ratio=2.996, 95% CI=1.611–5.572, P=0.001). According to the cell experiments, tumor cell proliferation, migration and invasion were suppressed by knockdown of HDAC9. CONCLUSION: All data demonstrated that overexpression of HDAC9 serves as a prognostic biomarker and may be involved in the tumor progression of breast cancer. |
format | Online Article Text |
id | pubmed-5909784 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-59097842018-04-30 Overexpression of HDAC9 is associated with poor prognosis and tumor progression of breast cancer in Chinese females Huang, Yixiang Jian, Wei Zhao, Junyong Wang, Gang Onco Targets Ther Original Research BACKGROUND: Breast cancer represents a serious health issue among females. HDAC9 has been identified as an oncogene in human cancers. This study sought to assess the prognostic value and the biologic function of HDAC9 in breast cancer patients. METHODS: Expression of HDAC9 in breast cancer tissues and cells was evaluated by quantitative real-time polymerase chain reaction. Kaplan–Meier survival analysis and Cox regression assay were conducted to explore the prognostic significance of HDAC9. Cell experiments were performed to investigate the effects of HDAC9 on the biologic behaviors of breast cancer cells. RESULTS: Expression of HDAC9 was significantly upregulated in both cancerous tissues and cells compared with the normal controls (all P<0.05). Overexpression of HDAC9 was correlated with lymph node metastasis (P=0.021) and TNM stage (P=0.004). Patients with high HDAC9 had poor overall survival compared to those with low levels of HDAC9 (log-rank P<0.05). Elevated HDAC9 was found to be an independent prognostic factor for the patients (hazard ratio=2.996, 95% CI=1.611–5.572, P=0.001). According to the cell experiments, tumor cell proliferation, migration and invasion were suppressed by knockdown of HDAC9. CONCLUSION: All data demonstrated that overexpression of HDAC9 serves as a prognostic biomarker and may be involved in the tumor progression of breast cancer. Dove Medical Press 2018-04-17 /pmc/articles/PMC5909784/ /pubmed/29713186 http://dx.doi.org/10.2147/OTT.S164583 Text en © 2018 Huang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Huang, Yixiang Jian, Wei Zhao, Junyong Wang, Gang Overexpression of HDAC9 is associated with poor prognosis and tumor progression of breast cancer in Chinese females |
title | Overexpression of HDAC9 is associated with poor prognosis and tumor progression of breast cancer in Chinese females |
title_full | Overexpression of HDAC9 is associated with poor prognosis and tumor progression of breast cancer in Chinese females |
title_fullStr | Overexpression of HDAC9 is associated with poor prognosis and tumor progression of breast cancer in Chinese females |
title_full_unstemmed | Overexpression of HDAC9 is associated with poor prognosis and tumor progression of breast cancer in Chinese females |
title_short | Overexpression of HDAC9 is associated with poor prognosis and tumor progression of breast cancer in Chinese females |
title_sort | overexpression of hdac9 is associated with poor prognosis and tumor progression of breast cancer in chinese females |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909784/ https://www.ncbi.nlm.nih.gov/pubmed/29713186 http://dx.doi.org/10.2147/OTT.S164583 |
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