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The role of Hippo signal pathway in breast cancer metastasis
The Hippo pathway is a novel and highly conserved mammalian signaling pathway. Mutations and altered expression of core Hippo pathway components promote the migration, invasion, malignancy, and chemotherapy resistance of breast cancer cells. In cancer metastasis, tumor cells must detach from the pri...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909795/ https://www.ncbi.nlm.nih.gov/pubmed/29713187 http://dx.doi.org/10.2147/OTT.S157058 |
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author | Wei, Changran Wang, Ying Li, Xiangqi |
author_facet | Wei, Changran Wang, Ying Li, Xiangqi |
author_sort | Wei, Changran |
collection | PubMed |
description | The Hippo pathway is a novel and highly conserved mammalian signaling pathway. Mutations and altered expression of core Hippo pathway components promote the migration, invasion, malignancy, and chemotherapy resistance of breast cancer cells. In cancer metastasis, tumor cells must detach from the primary tumor, invade surrounding tissue, and enter and survive in a foreign microenvironment. The metastatic potential of breast cancer is closely related to individual patient genetic profile. Nevertheless, the exact molecular mechanism that regulates the Hippo pathway in breast cancer metastasis is yet to be fully elucidated. This article discusses the function and regulation of the Hippo pathway, with focus given to its role in the context of breast cancer metastasis. |
format | Online Article Text |
id | pubmed-5909795 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-59097952018-04-30 The role of Hippo signal pathway in breast cancer metastasis Wei, Changran Wang, Ying Li, Xiangqi Onco Targets Ther Review The Hippo pathway is a novel and highly conserved mammalian signaling pathway. Mutations and altered expression of core Hippo pathway components promote the migration, invasion, malignancy, and chemotherapy resistance of breast cancer cells. In cancer metastasis, tumor cells must detach from the primary tumor, invade surrounding tissue, and enter and survive in a foreign microenvironment. The metastatic potential of breast cancer is closely related to individual patient genetic profile. Nevertheless, the exact molecular mechanism that regulates the Hippo pathway in breast cancer metastasis is yet to be fully elucidated. This article discusses the function and regulation of the Hippo pathway, with focus given to its role in the context of breast cancer metastasis. Dove Medical Press 2018-04-17 /pmc/articles/PMC5909795/ /pubmed/29713187 http://dx.doi.org/10.2147/OTT.S157058 Text en © 2018 Wei et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Wei, Changran Wang, Ying Li, Xiangqi The role of Hippo signal pathway in breast cancer metastasis |
title | The role of Hippo signal pathway in breast cancer metastasis |
title_full | The role of Hippo signal pathway in breast cancer metastasis |
title_fullStr | The role of Hippo signal pathway in breast cancer metastasis |
title_full_unstemmed | The role of Hippo signal pathway in breast cancer metastasis |
title_short | The role of Hippo signal pathway in breast cancer metastasis |
title_sort | role of hippo signal pathway in breast cancer metastasis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909795/ https://www.ncbi.nlm.nih.gov/pubmed/29713187 http://dx.doi.org/10.2147/OTT.S157058 |
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