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The role of Hippo signal pathway in breast cancer metastasis

The Hippo pathway is a novel and highly conserved mammalian signaling pathway. Mutations and altered expression of core Hippo pathway components promote the migration, invasion, malignancy, and chemotherapy resistance of breast cancer cells. In cancer metastasis, tumor cells must detach from the pri...

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Detalles Bibliográficos
Autores principales: Wei, Changran, Wang, Ying, Li, Xiangqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909795/
https://www.ncbi.nlm.nih.gov/pubmed/29713187
http://dx.doi.org/10.2147/OTT.S157058
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author Wei, Changran
Wang, Ying
Li, Xiangqi
author_facet Wei, Changran
Wang, Ying
Li, Xiangqi
author_sort Wei, Changran
collection PubMed
description The Hippo pathway is a novel and highly conserved mammalian signaling pathway. Mutations and altered expression of core Hippo pathway components promote the migration, invasion, malignancy, and chemotherapy resistance of breast cancer cells. In cancer metastasis, tumor cells must detach from the primary tumor, invade surrounding tissue, and enter and survive in a foreign microenvironment. The metastatic potential of breast cancer is closely related to individual patient genetic profile. Nevertheless, the exact molecular mechanism that regulates the Hippo pathway in breast cancer metastasis is yet to be fully elucidated. This article discusses the function and regulation of the Hippo pathway, with focus given to its role in the context of breast cancer metastasis.
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spelling pubmed-59097952018-04-30 The role of Hippo signal pathway in breast cancer metastasis Wei, Changran Wang, Ying Li, Xiangqi Onco Targets Ther Review The Hippo pathway is a novel and highly conserved mammalian signaling pathway. Mutations and altered expression of core Hippo pathway components promote the migration, invasion, malignancy, and chemotherapy resistance of breast cancer cells. In cancer metastasis, tumor cells must detach from the primary tumor, invade surrounding tissue, and enter and survive in a foreign microenvironment. The metastatic potential of breast cancer is closely related to individual patient genetic profile. Nevertheless, the exact molecular mechanism that regulates the Hippo pathway in breast cancer metastasis is yet to be fully elucidated. This article discusses the function and regulation of the Hippo pathway, with focus given to its role in the context of breast cancer metastasis. Dove Medical Press 2018-04-17 /pmc/articles/PMC5909795/ /pubmed/29713187 http://dx.doi.org/10.2147/OTT.S157058 Text en © 2018 Wei et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Wei, Changran
Wang, Ying
Li, Xiangqi
The role of Hippo signal pathway in breast cancer metastasis
title The role of Hippo signal pathway in breast cancer metastasis
title_full The role of Hippo signal pathway in breast cancer metastasis
title_fullStr The role of Hippo signal pathway in breast cancer metastasis
title_full_unstemmed The role of Hippo signal pathway in breast cancer metastasis
title_short The role of Hippo signal pathway in breast cancer metastasis
title_sort role of hippo signal pathway in breast cancer metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909795/
https://www.ncbi.nlm.nih.gov/pubmed/29713187
http://dx.doi.org/10.2147/OTT.S157058
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