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A haplotype of three SNPs in FTO had a strong association with body composition and BMI in Iranian male adolescents

BACKGROUND: Single-nucleotide polymorphisms (SNPs), which are located in the first intron of the FTO gene, are reported to be associated with body weight and the body mass index (BMI). However, their effects on anthropometric measurements in adolescents are poorly understood. OBJECTIVE: This study a...

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Autores principales: Kalantari, Naser, Keshavarz Mohammadi, Nastaran, Izadi, Pantea, Doaei, Saeid, Gholamalizadeh, Maryam, Eini-Zinab, Hassan, Salonurmi, Tuire, Rafieifar, Shahram, Janipoor, Reza, Azizi Tabesh, Ghasem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909891/
https://www.ncbi.nlm.nih.gov/pubmed/29677190
http://dx.doi.org/10.1371/journal.pone.0195589
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author Kalantari, Naser
Keshavarz Mohammadi, Nastaran
Izadi, Pantea
Doaei, Saeid
Gholamalizadeh, Maryam
Eini-Zinab, Hassan
Salonurmi, Tuire
Rafieifar, Shahram
Janipoor, Reza
Azizi Tabesh, Ghasem
author_facet Kalantari, Naser
Keshavarz Mohammadi, Nastaran
Izadi, Pantea
Doaei, Saeid
Gholamalizadeh, Maryam
Eini-Zinab, Hassan
Salonurmi, Tuire
Rafieifar, Shahram
Janipoor, Reza
Azizi Tabesh, Ghasem
author_sort Kalantari, Naser
collection PubMed
description BACKGROUND: Single-nucleotide polymorphisms (SNPs), which are located in the first intron of the FTO gene, are reported to be associated with body weight and the body mass index (BMI). However, their effects on anthropometric measurements in adolescents are poorly understood. OBJECTIVE: This study aimed to investigate the association of three adjacent polymorphisms (rs9930506, rs9930501, & rs9932754) in the FTO gene with anthropometric indices in Iranian adolescent males. DESIGN: The participants comprised a total of 237 adolescent males who were recruited randomly from two high schools in Tehran, Iran. The DNA samples were genotyped for the FTO gene polymorphisms by DNA sequencing. BMI, body fat percentage (BF%), and body muscle percentage (BM%) were determined using a validated bioelectrical impedance analysis scale. The association of the FTO polymorphisms with weight, height, BMI, BF%, and BM% was investigated. RESULTS: A haplotype of rs9930506, rs9930501, and rs9932754 (GGT) in the first intron of the FTO with complete linkage disequilibrium (LD) was found to be significantly associated with higher weight (OR = 1.32), BMI (OR = 5.36) and BF% (OR = 1.46), and lower BM% (OR = 3.59) (all P<0.001). None of the students with GGC genotypes were underweight, while all of the students with AAT genotypes had high muscle mass. CONCLUSIONS: A haplotype in the first intron of the FTO gene had a strong association with obesity indices in Iranian adolescent males. The FTO gene polymorphisms might have greater effects on anthropometric indices than what was previously imagined. Moreover, we suggested that the FTO gene exerted their effects on anthropometric measurements through haplotypes (and not single SNPs).
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spelling pubmed-59098912018-05-05 A haplotype of three SNPs in FTO had a strong association with body composition and BMI in Iranian male adolescents Kalantari, Naser Keshavarz Mohammadi, Nastaran Izadi, Pantea Doaei, Saeid Gholamalizadeh, Maryam Eini-Zinab, Hassan Salonurmi, Tuire Rafieifar, Shahram Janipoor, Reza Azizi Tabesh, Ghasem PLoS One Research Article BACKGROUND: Single-nucleotide polymorphisms (SNPs), which are located in the first intron of the FTO gene, are reported to be associated with body weight and the body mass index (BMI). However, their effects on anthropometric measurements in adolescents are poorly understood. OBJECTIVE: This study aimed to investigate the association of three adjacent polymorphisms (rs9930506, rs9930501, & rs9932754) in the FTO gene with anthropometric indices in Iranian adolescent males. DESIGN: The participants comprised a total of 237 adolescent males who were recruited randomly from two high schools in Tehran, Iran. The DNA samples were genotyped for the FTO gene polymorphisms by DNA sequencing. BMI, body fat percentage (BF%), and body muscle percentage (BM%) were determined using a validated bioelectrical impedance analysis scale. The association of the FTO polymorphisms with weight, height, BMI, BF%, and BM% was investigated. RESULTS: A haplotype of rs9930506, rs9930501, and rs9932754 (GGT) in the first intron of the FTO with complete linkage disequilibrium (LD) was found to be significantly associated with higher weight (OR = 1.32), BMI (OR = 5.36) and BF% (OR = 1.46), and lower BM% (OR = 3.59) (all P<0.001). None of the students with GGC genotypes were underweight, while all of the students with AAT genotypes had high muscle mass. CONCLUSIONS: A haplotype in the first intron of the FTO gene had a strong association with obesity indices in Iranian adolescent males. The FTO gene polymorphisms might have greater effects on anthropometric indices than what was previously imagined. Moreover, we suggested that the FTO gene exerted their effects on anthropometric measurements through haplotypes (and not single SNPs). Public Library of Science 2018-04-20 /pmc/articles/PMC5909891/ /pubmed/29677190 http://dx.doi.org/10.1371/journal.pone.0195589 Text en © 2018 Kalantari et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kalantari, Naser
Keshavarz Mohammadi, Nastaran
Izadi, Pantea
Doaei, Saeid
Gholamalizadeh, Maryam
Eini-Zinab, Hassan
Salonurmi, Tuire
Rafieifar, Shahram
Janipoor, Reza
Azizi Tabesh, Ghasem
A haplotype of three SNPs in FTO had a strong association with body composition and BMI in Iranian male adolescents
title A haplotype of three SNPs in FTO had a strong association with body composition and BMI in Iranian male adolescents
title_full A haplotype of three SNPs in FTO had a strong association with body composition and BMI in Iranian male adolescents
title_fullStr A haplotype of three SNPs in FTO had a strong association with body composition and BMI in Iranian male adolescents
title_full_unstemmed A haplotype of three SNPs in FTO had a strong association with body composition and BMI in Iranian male adolescents
title_short A haplotype of three SNPs in FTO had a strong association with body composition and BMI in Iranian male adolescents
title_sort haplotype of three snps in fto had a strong association with body composition and bmi in iranian male adolescents
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909891/
https://www.ncbi.nlm.nih.gov/pubmed/29677190
http://dx.doi.org/10.1371/journal.pone.0195589
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