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Synergistic interaction between a PDE5 inhibitor (sildenafil) and a new adenosine A(2A) receptor agonist (LASSBio-1359) improves pulmonary hypertension in rats

INTRODUCTION: Pulmonary hypertension (PH) is characterized by enhanced pulmonary vascular resistance, which causes right ventricle (RV) pressure overload and results in right sided heart failure and death. This work investigated the effectiveness of a combined therapy with PDE5 inhibitor (PDE5i) and...

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Detalles Bibliográficos
Autores principales:	Alencar, Allan K., Carvalho, Fábio I., Silva, Ananssa M., Martinez, Sabrina T., Calasans-Maia, Jorge A., Fraga, Carlos M., Barreiro, Eliezer J., Zapata-Sudo, Gisele, Sudo, Roberto T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909907/ https://www.ncbi.nlm.nih.gov/pubmed/29677206 http://dx.doi.org/10.1371/journal.pone.0195047

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