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A case report on the successful perioperative management of hepatectomy for hepatocellular carcinoma in a patient with von Willebrand disease
INTRODUCTION: Although von Willebrand disease (VWD) is a common inherited bleeding disorder, very few cases of surgery in patients with VWD have been reported. PRESENTATION OF CASE: A 77-year-old man was referred to our hospital for treatment of hepatocellular carcinoma (HCC) based on type C chronic...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910518/ https://www.ncbi.nlm.nih.gov/pubmed/29501017 http://dx.doi.org/10.1016/j.ijscr.2018.02.033 |
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author | Sato, Koki Kuroda, Shintaro Kobayashi, Tsuyoshi Shimizu, Seiichi Ohira, Masahiro Tahara, Hiroyuki Ide, Kentaro Fujii, Teruhisa Ohdan, Hideki |
author_facet | Sato, Koki Kuroda, Shintaro Kobayashi, Tsuyoshi Shimizu, Seiichi Ohira, Masahiro Tahara, Hiroyuki Ide, Kentaro Fujii, Teruhisa Ohdan, Hideki |
author_sort | Sato, Koki |
collection | PubMed |
description | INTRODUCTION: Although von Willebrand disease (VWD) is a common inherited bleeding disorder, very few cases of surgery in patients with VWD have been reported. PRESENTATION OF CASE: A 77-year-old man was referred to our hospital for treatment of hepatocellular carcinoma (HCC) based on type C chronic hepatitis. He had also been treated for VWD in the hematology department of another hospital. Partial hepatectomy was performed with the administration of factor VIII/von Willebrand factor concentrate just before and after the operation. The perioperative course was uneventful, and the patient was discharged 12 days after surgery. DISCUSSION: VWD causes dysfunction of the platelet and destabilization of the blood clotting factor VIII. The patient was successfully treated with measurement of activated partial thromboplastin time (APTT) as an index for the management of hemostasis. CONCLUSION: This report describes a rare case of a successful perioperative management of hepatectomy in a patient with VWD. |
format | Online Article Text |
id | pubmed-5910518 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-59105182018-04-23 A case report on the successful perioperative management of hepatectomy for hepatocellular carcinoma in a patient with von Willebrand disease Sato, Koki Kuroda, Shintaro Kobayashi, Tsuyoshi Shimizu, Seiichi Ohira, Masahiro Tahara, Hiroyuki Ide, Kentaro Fujii, Teruhisa Ohdan, Hideki Int J Surg Case Rep Article INTRODUCTION: Although von Willebrand disease (VWD) is a common inherited bleeding disorder, very few cases of surgery in patients with VWD have been reported. PRESENTATION OF CASE: A 77-year-old man was referred to our hospital for treatment of hepatocellular carcinoma (HCC) based on type C chronic hepatitis. He had also been treated for VWD in the hematology department of another hospital. Partial hepatectomy was performed with the administration of factor VIII/von Willebrand factor concentrate just before and after the operation. The perioperative course was uneventful, and the patient was discharged 12 days after surgery. DISCUSSION: VWD causes dysfunction of the platelet and destabilization of the blood clotting factor VIII. The patient was successfully treated with measurement of activated partial thromboplastin time (APTT) as an index for the management of hemostasis. CONCLUSION: This report describes a rare case of a successful perioperative management of hepatectomy in a patient with VWD. Elsevier 2018-02-24 /pmc/articles/PMC5910518/ /pubmed/29501017 http://dx.doi.org/10.1016/j.ijscr.2018.02.033 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Sato, Koki Kuroda, Shintaro Kobayashi, Tsuyoshi Shimizu, Seiichi Ohira, Masahiro Tahara, Hiroyuki Ide, Kentaro Fujii, Teruhisa Ohdan, Hideki A case report on the successful perioperative management of hepatectomy for hepatocellular carcinoma in a patient with von Willebrand disease |
title | A case report on the successful perioperative management of hepatectomy for hepatocellular carcinoma in a patient with von Willebrand disease |
title_full | A case report on the successful perioperative management of hepatectomy for hepatocellular carcinoma in a patient with von Willebrand disease |
title_fullStr | A case report on the successful perioperative management of hepatectomy for hepatocellular carcinoma in a patient with von Willebrand disease |
title_full_unstemmed | A case report on the successful perioperative management of hepatectomy for hepatocellular carcinoma in a patient with von Willebrand disease |
title_short | A case report on the successful perioperative management of hepatectomy for hepatocellular carcinoma in a patient with von Willebrand disease |
title_sort | case report on the successful perioperative management of hepatectomy for hepatocellular carcinoma in a patient with von willebrand disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910518/ https://www.ncbi.nlm.nih.gov/pubmed/29501017 http://dx.doi.org/10.1016/j.ijscr.2018.02.033 |
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