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Risk factors of renal dysfunction and their interaction in level-low lead exposure paint workers
BACKGROUND: To explore the effect of low-level lead exposure on renal dysfunction in paint works, and analyze the interaction between low-level lead exposure and other influence factors of renal dysfunction. METHODS: Seven hundred forty seven workers from Sany Heavy Industry Company and Xiangjiang K...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910569/ https://www.ncbi.nlm.nih.gov/pubmed/29678135 http://dx.doi.org/10.1186/s12889-018-5475-9 |
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author | Wang, Xiaojuan Liang, Huiling Wang, Yan Cai, Chang Li, Jimeng Li, Xun Wang, Mian Chen, Mengshi Xu, Xin Tan, Hongzhuan |
author_facet | Wang, Xiaojuan Liang, Huiling Wang, Yan Cai, Chang Li, Jimeng Li, Xun Wang, Mian Chen, Mengshi Xu, Xin Tan, Hongzhuan |
author_sort | Wang, Xiaojuan |
collection | PubMed |
description | BACKGROUND: To explore the effect of low-level lead exposure on renal dysfunction in paint works, and analyze the interaction between low-level lead exposure and other influence factors of renal dysfunction. METHODS: Seven hundred forty seven workers from Sany Heavy Industry Company and Xiangjiang Kansai Paint Company who have been exposed to paint were chosen by random cluster sampling. Their blood lead level and Urine β2-micro globulin level (renal dysfunction) were tested,risk factors of renal dysfunction in paint workers and their interactions were analyzed. RESULTS: The prevalence of renal dysfunction was 12.37%. Risk factors of renal dysfunction in paint workers mainly included longer working years (OR = 1.699, 95% CI: 1.226~ 2.355), blood lead positive (OR = 2.847, 95% CI: 1.577~ 5.139) and hypertension (OR = 2.192, 95% CI: 1.103~ 4.359). Positive interaction existed between hypertension and low-level blood lead on renal dysfunction in paint workers, the RERI (Relative excess risk of interaction), API (Attributable proportions of interaction) and S(the synergy index) were 4.758, 54.5% and 2.604 respectively. CONCLUSIONS: Low-level lead exposure and hypertension not only have independent effect on renal dysfunction in paint workers, but also had obvious positive interaction in paint workers. Interventions aimed at blood lead and blood pressure at the same time will better prenvent from renal dysfunction. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12889-018-5475-9) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5910569 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-59105692018-05-02 Risk factors of renal dysfunction and their interaction in level-low lead exposure paint workers Wang, Xiaojuan Liang, Huiling Wang, Yan Cai, Chang Li, Jimeng Li, Xun Wang, Mian Chen, Mengshi Xu, Xin Tan, Hongzhuan BMC Public Health Research Article BACKGROUND: To explore the effect of low-level lead exposure on renal dysfunction in paint works, and analyze the interaction between low-level lead exposure and other influence factors of renal dysfunction. METHODS: Seven hundred forty seven workers from Sany Heavy Industry Company and Xiangjiang Kansai Paint Company who have been exposed to paint were chosen by random cluster sampling. Their blood lead level and Urine β2-micro globulin level (renal dysfunction) were tested,risk factors of renal dysfunction in paint workers and their interactions were analyzed. RESULTS: The prevalence of renal dysfunction was 12.37%. Risk factors of renal dysfunction in paint workers mainly included longer working years (OR = 1.699, 95% CI: 1.226~ 2.355), blood lead positive (OR = 2.847, 95% CI: 1.577~ 5.139) and hypertension (OR = 2.192, 95% CI: 1.103~ 4.359). Positive interaction existed between hypertension and low-level blood lead on renal dysfunction in paint workers, the RERI (Relative excess risk of interaction), API (Attributable proportions of interaction) and S(the synergy index) were 4.758, 54.5% and 2.604 respectively. CONCLUSIONS: Low-level lead exposure and hypertension not only have independent effect on renal dysfunction in paint workers, but also had obvious positive interaction in paint workers. Interventions aimed at blood lead and blood pressure at the same time will better prenvent from renal dysfunction. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12889-018-5475-9) contains supplementary material, which is available to authorized users. BioMed Central 2018-04-20 /pmc/articles/PMC5910569/ /pubmed/29678135 http://dx.doi.org/10.1186/s12889-018-5475-9 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Wang, Xiaojuan Liang, Huiling Wang, Yan Cai, Chang Li, Jimeng Li, Xun Wang, Mian Chen, Mengshi Xu, Xin Tan, Hongzhuan Risk factors of renal dysfunction and their interaction in level-low lead exposure paint workers |
title | Risk factors of renal dysfunction and their interaction in level-low lead exposure paint workers |
title_full | Risk factors of renal dysfunction and their interaction in level-low lead exposure paint workers |
title_fullStr | Risk factors of renal dysfunction and their interaction in level-low lead exposure paint workers |
title_full_unstemmed | Risk factors of renal dysfunction and their interaction in level-low lead exposure paint workers |
title_short | Risk factors of renal dysfunction and their interaction in level-low lead exposure paint workers |
title_sort | risk factors of renal dysfunction and their interaction in level-low lead exposure paint workers |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910569/ https://www.ncbi.nlm.nih.gov/pubmed/29678135 http://dx.doi.org/10.1186/s12889-018-5475-9 |
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