Cargando…
Potential role of cyanidin 3-glucoside (C3G) in diabetic cardiomyopathy in diabetic rats: An in vivo approach
The present study aimed to evaluate the importance of cyanidin 3-glucoside (C3G) of diabetic cardiomyopathy in diabetic rats. The rats were induced with diabetic using streptozotocin and total triglyceride (TG) and total cholesterol (TC) were determined. The range of myocardial enzymes such as aspar...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910639/ https://www.ncbi.nlm.nih.gov/pubmed/29686513 http://dx.doi.org/10.1016/j.sjbs.2016.11.007 |
_version_ | 1783316093865033728 |
---|---|
author | Li, Weizhen Chen, Songwen Zhou, Genqing Li, Hongli Zhong, Lan Liu, Shaowen |
author_facet | Li, Weizhen Chen, Songwen Zhou, Genqing Li, Hongli Zhong, Lan Liu, Shaowen |
author_sort | Li, Weizhen |
collection | PubMed |
description | The present study aimed to evaluate the importance of cyanidin 3-glucoside (C3G) of diabetic cardiomyopathy in diabetic rats. The rats were induced with diabetic using streptozotocin and total triglyceride (TG) and total cholesterol (TC) were determined. The range of myocardial enzymes such as aspartate aminotransferase (AST), creatine kinase (CK) and lactate dehydrogenase (LD) were also estimated, further, the Immuno histochemical analysis and western blot investigation were determined for the actual activity of C3G. Results indicated that the marker enzymes such as CK, LD and AST were significantly (P < 0.05) increased in STZ administered rats (DM group), while the levels of these elevated marker enzymes of cardiac injury significantly (P < 0.05) declined in the DM + C3G group, as compared to the diabetic group of rats. Additionally, a decrease in the level of TNF-alpha and interleukin-6, was noticed in the C3G treated group as compared to diabetic group. Finally, blotting analysis clearly confirmed that theC3G treatment resulted to higher level response of Bcl-2 and lower level response of caspase-3 and BAX. In conclusion, C3G a natural antioxidant may prevent cardiovascular complications by ameliorating oxidative damage, inflammation, metabolic dysfunctions and apoptosis pathways in type 2 diabetes. |
format | Online Article Text |
id | pubmed-5910639 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-59106392018-04-23 Potential role of cyanidin 3-glucoside (C3G) in diabetic cardiomyopathy in diabetic rats: An in vivo approach Li, Weizhen Chen, Songwen Zhou, Genqing Li, Hongli Zhong, Lan Liu, Shaowen Saudi J Biol Sci Article The present study aimed to evaluate the importance of cyanidin 3-glucoside (C3G) of diabetic cardiomyopathy in diabetic rats. The rats were induced with diabetic using streptozotocin and total triglyceride (TG) and total cholesterol (TC) were determined. The range of myocardial enzymes such as aspartate aminotransferase (AST), creatine kinase (CK) and lactate dehydrogenase (LD) were also estimated, further, the Immuno histochemical analysis and western blot investigation were determined for the actual activity of C3G. Results indicated that the marker enzymes such as CK, LD and AST were significantly (P < 0.05) increased in STZ administered rats (DM group), while the levels of these elevated marker enzymes of cardiac injury significantly (P < 0.05) declined in the DM + C3G group, as compared to the diabetic group of rats. Additionally, a decrease in the level of TNF-alpha and interleukin-6, was noticed in the C3G treated group as compared to diabetic group. Finally, blotting analysis clearly confirmed that theC3G treatment resulted to higher level response of Bcl-2 and lower level response of caspase-3 and BAX. In conclusion, C3G a natural antioxidant may prevent cardiovascular complications by ameliorating oxidative damage, inflammation, metabolic dysfunctions and apoptosis pathways in type 2 diabetes. Elsevier 2018-03 2016-11-10 /pmc/articles/PMC5910639/ /pubmed/29686513 http://dx.doi.org/10.1016/j.sjbs.2016.11.007 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Li, Weizhen Chen, Songwen Zhou, Genqing Li, Hongli Zhong, Lan Liu, Shaowen Potential role of cyanidin 3-glucoside (C3G) in diabetic cardiomyopathy in diabetic rats: An in vivo approach |
title | Potential role of cyanidin 3-glucoside (C3G) in diabetic cardiomyopathy in diabetic rats: An in vivo approach |
title_full | Potential role of cyanidin 3-glucoside (C3G) in diabetic cardiomyopathy in diabetic rats: An in vivo approach |
title_fullStr | Potential role of cyanidin 3-glucoside (C3G) in diabetic cardiomyopathy in diabetic rats: An in vivo approach |
title_full_unstemmed | Potential role of cyanidin 3-glucoside (C3G) in diabetic cardiomyopathy in diabetic rats: An in vivo approach |
title_short | Potential role of cyanidin 3-glucoside (C3G) in diabetic cardiomyopathy in diabetic rats: An in vivo approach |
title_sort | potential role of cyanidin 3-glucoside (c3g) in diabetic cardiomyopathy in diabetic rats: an in vivo approach |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910639/ https://www.ncbi.nlm.nih.gov/pubmed/29686513 http://dx.doi.org/10.1016/j.sjbs.2016.11.007 |
work_keys_str_mv | AT liweizhen potentialroleofcyanidin3glucosidec3gindiabeticcardiomyopathyindiabeticratsaninvivoapproach AT chensongwen potentialroleofcyanidin3glucosidec3gindiabeticcardiomyopathyindiabeticratsaninvivoapproach AT zhougenqing potentialroleofcyanidin3glucosidec3gindiabeticcardiomyopathyindiabeticratsaninvivoapproach AT lihongli potentialroleofcyanidin3glucosidec3gindiabeticcardiomyopathyindiabeticratsaninvivoapproach AT zhonglan potentialroleofcyanidin3glucosidec3gindiabeticcardiomyopathyindiabeticratsaninvivoapproach AT liushaowen potentialroleofcyanidin3glucosidec3gindiabeticcardiomyopathyindiabeticratsaninvivoapproach |