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Insight from the maximal activation of the signal transduction excitable network in Dictyostelium discoideum
Cell migration requires the coordination of an excitable signal transduction network involving Ras and PI3K pathways with cytoskeletal activity. We show that expressing activated Ras GTPase-family proteins in cells lacking PTEN or other mutations which increase cellular protrusiveness transforms cel...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910810/ https://www.ncbi.nlm.nih.gov/pubmed/29602807 http://dx.doi.org/10.1073/pnas.1710480115 |