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Insight from the maximal activation of the signal transduction excitable network in Dictyostelium discoideum

Cell migration requires the coordination of an excitable signal transduction network involving Ras and PI3K pathways with cytoskeletal activity. We show that expressing activated Ras GTPase-family proteins in cells lacking PTEN or other mutations which increase cellular protrusiveness transforms cel...

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Detalles Bibliográficos
Autores principales:	Edwards, Marc, Cai, Huaqing, Abubaker-Sharif, Bedri, Long, Yu, Lampert, Thomas J., Devreotes, Peter N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2018
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910810/ https://www.ncbi.nlm.nih.gov/pubmed/29602807 http://dx.doi.org/10.1073/pnas.1710480115

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