Cargando…

Human bony labyrinth is an indicator of population history and dispersal from Africa

The dispersal of modern humans from Africa is now well documented with genetic data that track population history, as well as gene flow between populations. Phenetic skeletal data, such as cranial and pelvic morphologies, also exhibit a dispersal-from-Africa signal, which, however, tends to be blurr...

Descripción completa

Detalles Bibliográficos
Autores principales: Ponce de León, Marcia S., Koesbardiati, Toetik, Weissmann, John David, Milella, Marco, Reyna-Blanco, Carlos S., Suwa, Gen, Kondo, Osamu, Malaspinas, Anna-Sapfo, White, Tim D., Zollikofer, Christoph P. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910833/
https://www.ncbi.nlm.nih.gov/pubmed/29610337
http://dx.doi.org/10.1073/pnas.1717873115
_version_ 1783316126352015360
author Ponce de León, Marcia S.
Koesbardiati, Toetik
Weissmann, John David
Milella, Marco
Reyna-Blanco, Carlos S.
Suwa, Gen
Kondo, Osamu
Malaspinas, Anna-Sapfo
White, Tim D.
Zollikofer, Christoph P. E.
author_facet Ponce de León, Marcia S.
Koesbardiati, Toetik
Weissmann, John David
Milella, Marco
Reyna-Blanco, Carlos S.
Suwa, Gen
Kondo, Osamu
Malaspinas, Anna-Sapfo
White, Tim D.
Zollikofer, Christoph P. E.
author_sort Ponce de León, Marcia S.
collection PubMed
description The dispersal of modern humans from Africa is now well documented with genetic data that track population history, as well as gene flow between populations. Phenetic skeletal data, such as cranial and pelvic morphologies, also exhibit a dispersal-from-Africa signal, which, however, tends to be blurred by the effects of local adaptation and in vivo phenotypic plasticity, and that is often deteriorated by postmortem damage to skeletal remains. These complexities raise the question of which skeletal structures most effectively track neutral population history. The cavity system of the inner ear (the so-called bony labyrinth) is a good candidate structure for such analyses. It is already fully formed by birth, which minimizes postnatal phenotypic plasticity, and it is generally well preserved in archaeological samples. Here we use morphometric data of the bony labyrinth to show that it is a surprisingly good marker of the global dispersal of modern humans from Africa. Labyrinthine morphology tracks genetic distances and geography in accordance with an isolation-by-distance model with dispersal from Africa. Our data further indicate that the neutral-like pattern of variation is compatible with stabilizing selection on labyrinth morphology. Given the increasingly important role of the petrous bone for ancient DNA recovery from archaeological specimens, we encourage researchers to acquire 3D morphological data of the inner ear structures before any invasive sampling. Such data will constitute an important archive of phenotypic variation in present and past populations, and will permit individual-based genotype–phenotype comparisons.
format Online
Article
Text
id pubmed-5910833
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher National Academy of Sciences
record_format MEDLINE/PubMed
spelling pubmed-59108332018-04-25 Human bony labyrinth is an indicator of population history and dispersal from Africa Ponce de León, Marcia S. Koesbardiati, Toetik Weissmann, John David Milella, Marco Reyna-Blanco, Carlos S. Suwa, Gen Kondo, Osamu Malaspinas, Anna-Sapfo White, Tim D. Zollikofer, Christoph P. E. Proc Natl Acad Sci U S A Biological Sciences The dispersal of modern humans from Africa is now well documented with genetic data that track population history, as well as gene flow between populations. Phenetic skeletal data, such as cranial and pelvic morphologies, also exhibit a dispersal-from-Africa signal, which, however, tends to be blurred by the effects of local adaptation and in vivo phenotypic plasticity, and that is often deteriorated by postmortem damage to skeletal remains. These complexities raise the question of which skeletal structures most effectively track neutral population history. The cavity system of the inner ear (the so-called bony labyrinth) is a good candidate structure for such analyses. It is already fully formed by birth, which minimizes postnatal phenotypic plasticity, and it is generally well preserved in archaeological samples. Here we use morphometric data of the bony labyrinth to show that it is a surprisingly good marker of the global dispersal of modern humans from Africa. Labyrinthine morphology tracks genetic distances and geography in accordance with an isolation-by-distance model with dispersal from Africa. Our data further indicate that the neutral-like pattern of variation is compatible with stabilizing selection on labyrinth morphology. Given the increasingly important role of the petrous bone for ancient DNA recovery from archaeological specimens, we encourage researchers to acquire 3D morphological data of the inner ear structures before any invasive sampling. Such data will constitute an important archive of phenotypic variation in present and past populations, and will permit individual-based genotype–phenotype comparisons. National Academy of Sciences 2018-04-17 2018-04-02 /pmc/articles/PMC5910833/ /pubmed/29610337 http://dx.doi.org/10.1073/pnas.1717873115 Text en Copyright © 2018 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/ This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Ponce de León, Marcia S.
Koesbardiati, Toetik
Weissmann, John David
Milella, Marco
Reyna-Blanco, Carlos S.
Suwa, Gen
Kondo, Osamu
Malaspinas, Anna-Sapfo
White, Tim D.
Zollikofer, Christoph P. E.
Human bony labyrinth is an indicator of population history and dispersal from Africa
title Human bony labyrinth is an indicator of population history and dispersal from Africa
title_full Human bony labyrinth is an indicator of population history and dispersal from Africa
title_fullStr Human bony labyrinth is an indicator of population history and dispersal from Africa
title_full_unstemmed Human bony labyrinth is an indicator of population history and dispersal from Africa
title_short Human bony labyrinth is an indicator of population history and dispersal from Africa
title_sort human bony labyrinth is an indicator of population history and dispersal from africa
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910833/
https://www.ncbi.nlm.nih.gov/pubmed/29610337
http://dx.doi.org/10.1073/pnas.1717873115
work_keys_str_mv AT poncedeleonmarcias humanbonylabyrinthisanindicatorofpopulationhistoryanddispersalfromafrica
AT koesbardiatitoetik humanbonylabyrinthisanindicatorofpopulationhistoryanddispersalfromafrica
AT weissmannjohndavid humanbonylabyrinthisanindicatorofpopulationhistoryanddispersalfromafrica
AT milellamarco humanbonylabyrinthisanindicatorofpopulationhistoryanddispersalfromafrica
AT reynablancocarloss humanbonylabyrinthisanindicatorofpopulationhistoryanddispersalfromafrica
AT suwagen humanbonylabyrinthisanindicatorofpopulationhistoryanddispersalfromafrica
AT kondoosamu humanbonylabyrinthisanindicatorofpopulationhistoryanddispersalfromafrica
AT malaspinasannasapfo humanbonylabyrinthisanindicatorofpopulationhistoryanddispersalfromafrica
AT whitetimd humanbonylabyrinthisanindicatorofpopulationhistoryanddispersalfromafrica
AT zollikoferchristophpe humanbonylabyrinthisanindicatorofpopulationhistoryanddispersalfromafrica