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Lateral Hypothalamus as a Motivation-Cognition Interface in the Control of Feeding Behavior

Converging evidence for an essential function of the lateral hypothalamus (LHA) in the control of feeding behavior has been accumulating since the classic work conducted almost 80 years ago. The LHA is also important in reward and reinforcement processes and behavioral state control. A unifying func...

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Autor principal: Petrovich, Gorica D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911470/
https://www.ncbi.nlm.nih.gov/pubmed/29713268
http://dx.doi.org/10.3389/fnsys.2018.00014
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author Petrovich, Gorica D.
author_facet Petrovich, Gorica D.
author_sort Petrovich, Gorica D.
collection PubMed
description Converging evidence for an essential function of the lateral hypothalamus (LHA) in the control of feeding behavior has been accumulating since the classic work conducted almost 80 years ago. The LHA is also important in reward and reinforcement processes and behavioral state control. A unifying function for the LHA across these processes has not been fully established. Nonetheless, it is considered to integrate motivation with behavior. More recent work has demonstrated that the LHA is also required when cognitive processes, such as associative learning and memory control feeding behavior, suggesting it may serve as a motivation-cognition interface. Structurally, the LHA is well positioned within the cerebral hemisphere, with its extensive connectional network across the forebrain-brainstem axis, to link motivational and behavioral systems with cognitive processes. Studies that examined how learned cues control food seeking and consumption have implicated the LHA, but due to methodological limitations could not determine whether it underlies motivation, learning, or the integration of these processes. Furthermore, the identification of specific substrates has been limited by the LHA’s extraordinary complexity and heterogeneity. Recent methodological advancements with chemo-and opto-genetic approaches have enabled unprecedented specificity in interrogations of distinct neurons and their pathways in behaving animals, including manipulations during temporally distinct events. These approaches have revealed novel insights about the LHA structure and function. Recent findings that the GABA LHA neurons control feeding and food-reward learning and memory will be reviewed together with past work within the context of the LHA function as an interface between cognition and motivation.
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spelling pubmed-59114702018-04-30 Lateral Hypothalamus as a Motivation-Cognition Interface in the Control of Feeding Behavior Petrovich, Gorica D. Front Syst Neurosci Neuroscience Converging evidence for an essential function of the lateral hypothalamus (LHA) in the control of feeding behavior has been accumulating since the classic work conducted almost 80 years ago. The LHA is also important in reward and reinforcement processes and behavioral state control. A unifying function for the LHA across these processes has not been fully established. Nonetheless, it is considered to integrate motivation with behavior. More recent work has demonstrated that the LHA is also required when cognitive processes, such as associative learning and memory control feeding behavior, suggesting it may serve as a motivation-cognition interface. Structurally, the LHA is well positioned within the cerebral hemisphere, with its extensive connectional network across the forebrain-brainstem axis, to link motivational and behavioral systems with cognitive processes. Studies that examined how learned cues control food seeking and consumption have implicated the LHA, but due to methodological limitations could not determine whether it underlies motivation, learning, or the integration of these processes. Furthermore, the identification of specific substrates has been limited by the LHA’s extraordinary complexity and heterogeneity. Recent methodological advancements with chemo-and opto-genetic approaches have enabled unprecedented specificity in interrogations of distinct neurons and their pathways in behaving animals, including manipulations during temporally distinct events. These approaches have revealed novel insights about the LHA structure and function. Recent findings that the GABA LHA neurons control feeding and food-reward learning and memory will be reviewed together with past work within the context of the LHA function as an interface between cognition and motivation. Frontiers Media S.A. 2018-04-16 /pmc/articles/PMC5911470/ /pubmed/29713268 http://dx.doi.org/10.3389/fnsys.2018.00014 Text en Copyright © 2018 Petrovich. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Petrovich, Gorica D.
Lateral Hypothalamus as a Motivation-Cognition Interface in the Control of Feeding Behavior
title Lateral Hypothalamus as a Motivation-Cognition Interface in the Control of Feeding Behavior
title_full Lateral Hypothalamus as a Motivation-Cognition Interface in the Control of Feeding Behavior
title_fullStr Lateral Hypothalamus as a Motivation-Cognition Interface in the Control of Feeding Behavior
title_full_unstemmed Lateral Hypothalamus as a Motivation-Cognition Interface in the Control of Feeding Behavior
title_short Lateral Hypothalamus as a Motivation-Cognition Interface in the Control of Feeding Behavior
title_sort lateral hypothalamus as a motivation-cognition interface in the control of feeding behavior
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911470/
https://www.ncbi.nlm.nih.gov/pubmed/29713268
http://dx.doi.org/10.3389/fnsys.2018.00014
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