Sequence-dependent attack on peptides by photoactivated platinum anticancer complexes

Octahedral platinum(iv) complexes such as trans,trans,trans-[Pt(N(3))(2)(OH)(2)(pyridine)(2)] (1) are stable in the dark, but potently cytotoxic to a range of cancer cells when activated by UVA or visible light, and active in vivo. Photoactivation causes the reduction of the complex and leads to the...

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Detalles Bibliográficos
Autores principales: Wootton, Christopher A., Sanchez-Cano, Carlos, Lopez-Clavijo, Andrea F., Shaili, Evyenia, Barrow, Mark P., Sadler, Peter J., O'Connor, Peter B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911824/
https://www.ncbi.nlm.nih.gov/pubmed/29732057
http://dx.doi.org/10.1039/c7sc05135b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911824/
https://www.ncbi.nlm.nih.gov/pubmed/29732057
http://dx.doi.org/10.1039/c7sc05135b

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