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Association of Source of Memory Complaints and Increased Risk of Cognitive Impairment and Cognitive Decline: A Community-Based Study

BACKGROUND: Memory complaint is common in the elderly. Recently, it was shown that self-report memory complaint was predictive of cognitive decline. This study aimed to investigate the predictive value of the source of memory complaints on the risk of cognitive impairment and cognitive decline in a...

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Autores principales: Qi, Xue-Mei, Gu, Lin, Tang, Hui-Dong, Chen, Sheng-Di, Ma, Jian-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912053/
https://www.ncbi.nlm.nih.gov/pubmed/29664047
http://dx.doi.org/10.4103/0366-6999.229904
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author Qi, Xue-Mei
Gu, Lin
Tang, Hui-Dong
Chen, Sheng-Di
Ma, Jian-Fang
author_facet Qi, Xue-Mei
Gu, Lin
Tang, Hui-Dong
Chen, Sheng-Di
Ma, Jian-Fang
author_sort Qi, Xue-Mei
collection PubMed
description BACKGROUND: Memory complaint is common in the elderly. Recently, it was shown that self-report memory complaint was predictive of cognitive decline. This study aimed to investigate the predictive value of the source of memory complaints on the risk of cognitive impairment and cognitive decline in a community-based cohort. METHODS: Data on memory complaints and cognitive function were collected among 1840 Chinese participants (aged ≥55 years old) in an urban community at baseline interview and 5-year follow-up. Incident cognitive impairment was identified based on education-adjusted Mini-Mental State Examination score. Logistic regression model was used to estimate the association between the source of memory complaints and risk of cognitive impairment conversion and cognitive decline, after adjusting for covariates. RESULTS: A total of 1840 participants were included into this study including 1713 normal participants and 127 cognitive impairment participants in 2009. Among 1713 normal participants in 2009, 130 participants were converted to cognitive impairment after 5 years of follow-up. In 2014, 606 participants were identified as cognitive decline. Both self- and informant-reported memory complaints were associated with an increased risk of cognitive impairment (odds ratio [OR] = 1.60, 95% confidence interval [CI]: 1.04–2.48) and cognitive decline (OR = 1.30, 95% CI: 1.01–1.68). Furthermore, this association was more significant in males (OR = 2.10, 95% CI: 1.04–4.24 for cognitive impairment and OR = 1.87, 95% CI: 1.20–2.99 for cognitive decline) and in higher education level (OR = 1.79, 95% CI: 1.02–3.15 for cognitive impairment and OR = 1.40, 95% CI: 1.02–1.91 for cognitive decline). CONCLUSIONS: Both self- and informant-reported memory complaints were associated with an increased risk of cognitive impairment conversion and cognitive decline, especially in persons with male gender and high educational background.
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spelling pubmed-59120532018-05-03 Association of Source of Memory Complaints and Increased Risk of Cognitive Impairment and Cognitive Decline: A Community-Based Study Qi, Xue-Mei Gu, Lin Tang, Hui-Dong Chen, Sheng-Di Ma, Jian-Fang Chin Med J (Engl) Original Article BACKGROUND: Memory complaint is common in the elderly. Recently, it was shown that self-report memory complaint was predictive of cognitive decline. This study aimed to investigate the predictive value of the source of memory complaints on the risk of cognitive impairment and cognitive decline in a community-based cohort. METHODS: Data on memory complaints and cognitive function were collected among 1840 Chinese participants (aged ≥55 years old) in an urban community at baseline interview and 5-year follow-up. Incident cognitive impairment was identified based on education-adjusted Mini-Mental State Examination score. Logistic regression model was used to estimate the association between the source of memory complaints and risk of cognitive impairment conversion and cognitive decline, after adjusting for covariates. RESULTS: A total of 1840 participants were included into this study including 1713 normal participants and 127 cognitive impairment participants in 2009. Among 1713 normal participants in 2009, 130 participants were converted to cognitive impairment after 5 years of follow-up. In 2014, 606 participants were identified as cognitive decline. Both self- and informant-reported memory complaints were associated with an increased risk of cognitive impairment (odds ratio [OR] = 1.60, 95% confidence interval [CI]: 1.04–2.48) and cognitive decline (OR = 1.30, 95% CI: 1.01–1.68). Furthermore, this association was more significant in males (OR = 2.10, 95% CI: 1.04–4.24 for cognitive impairment and OR = 1.87, 95% CI: 1.20–2.99 for cognitive decline) and in higher education level (OR = 1.79, 95% CI: 1.02–3.15 for cognitive impairment and OR = 1.40, 95% CI: 1.02–1.91 for cognitive decline). CONCLUSIONS: Both self- and informant-reported memory complaints were associated with an increased risk of cognitive impairment conversion and cognitive decline, especially in persons with male gender and high educational background. Medknow Publications & Media Pvt Ltd 2018-04-20 /pmc/articles/PMC5912053/ /pubmed/29664047 http://dx.doi.org/10.4103/0366-6999.229904 Text en Copyright: © 2018 Chinese Medical Journal http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Qi, Xue-Mei
Gu, Lin
Tang, Hui-Dong
Chen, Sheng-Di
Ma, Jian-Fang
Association of Source of Memory Complaints and Increased Risk of Cognitive Impairment and Cognitive Decline: A Community-Based Study
title Association of Source of Memory Complaints and Increased Risk of Cognitive Impairment and Cognitive Decline: A Community-Based Study
title_full Association of Source of Memory Complaints and Increased Risk of Cognitive Impairment and Cognitive Decline: A Community-Based Study
title_fullStr Association of Source of Memory Complaints and Increased Risk of Cognitive Impairment and Cognitive Decline: A Community-Based Study
title_full_unstemmed Association of Source of Memory Complaints and Increased Risk of Cognitive Impairment and Cognitive Decline: A Community-Based Study
title_short Association of Source of Memory Complaints and Increased Risk of Cognitive Impairment and Cognitive Decline: A Community-Based Study
title_sort association of source of memory complaints and increased risk of cognitive impairment and cognitive decline: a community-based study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912053/
https://www.ncbi.nlm.nih.gov/pubmed/29664047
http://dx.doi.org/10.4103/0366-6999.229904
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