Low density lipoprotein modified silica nanoparticles loaded with docetaxel and thalidomide for effective chemotherapy of liver cancer

In the present study, we successfully developed a docetaxel (DTX) and thalidomide (TDD) co-delivery system based on low density lipoprotein (LDL) modified silica nanoparticles (LDL/SLN/DTX/TDD). By employing the tumor homing property of LDL and the drug-loading capability of silica nanoparticles, th...

Descripción completa

Detalles Bibliográficos
Autores principales: Ao, Man, Xiao, Xu, Ao, Yazhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912100/
https://www.ncbi.nlm.nih.gov/pubmed/29513882
http://dx.doi.org/10.1590/1414-431X20176650
_version_ 1783316337134665728
author Ao, Man
Xiao, Xu
Ao, Yazhou
author_facet Ao, Man
Xiao, Xu
Ao, Yazhou
author_sort Ao, Man
collection PubMed
description In the present study, we successfully developed a docetaxel (DTX) and thalidomide (TDD) co-delivery system based on low density lipoprotein (LDL) modified silica nanoparticles (LDL/SLN/DTX/TDD). By employing the tumor homing property of LDL and the drug-loading capability of silica nanoparticles, the prepared LDL/SLN/DTX/TDD was expected to locate and specifically deliver the loaded drugs (DTX and TDD) to achieve effective chemotherapy of liver cancer. In vitro analysis revealed that nano-sized LDL/SLN/DTX/TDD with decent drug loading capabilities was able to increase the delivery efficiency by targeting the low density lipoprotein receptors, which were overexpressed on HepG2 human hepatocellular liver carcinoma cell line, which exerted better cytotoxicity than unmodified silica nanoparticles and free drugs. In vivo imaging and anti-cancer assays also confirmed the preferable tumor-homing and synergetic anti-cancer effects of LDL/SLN/DTX/TDD.
format Online
Article
Text
id pubmed-5912100
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Associação Brasileira de Divulgação Científica
record_format MEDLINE/PubMed
spelling pubmed-59121002018-04-23 Low density lipoprotein modified silica nanoparticles loaded with docetaxel and thalidomide for effective chemotherapy of liver cancer Ao, Man Xiao, Xu Ao, Yazhou Braz J Med Biol Res Research Articles In the present study, we successfully developed a docetaxel (DTX) and thalidomide (TDD) co-delivery system based on low density lipoprotein (LDL) modified silica nanoparticles (LDL/SLN/DTX/TDD). By employing the tumor homing property of LDL and the drug-loading capability of silica nanoparticles, the prepared LDL/SLN/DTX/TDD was expected to locate and specifically deliver the loaded drugs (DTX and TDD) to achieve effective chemotherapy of liver cancer. In vitro analysis revealed that nano-sized LDL/SLN/DTX/TDD with decent drug loading capabilities was able to increase the delivery efficiency by targeting the low density lipoprotein receptors, which were overexpressed on HepG2 human hepatocellular liver carcinoma cell line, which exerted better cytotoxicity than unmodified silica nanoparticles and free drugs. In vivo imaging and anti-cancer assays also confirmed the preferable tumor-homing and synergetic anti-cancer effects of LDL/SLN/DTX/TDD. Associação Brasileira de Divulgação Científica 2018-03-01 /pmc/articles/PMC5912100/ /pubmed/29513882 http://dx.doi.org/10.1590/1414-431X20176650 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Ao, Man
Xiao, Xu
Ao, Yazhou
Low density lipoprotein modified silica nanoparticles loaded with docetaxel and thalidomide for effective chemotherapy of liver cancer
title Low density lipoprotein modified silica nanoparticles loaded with docetaxel and thalidomide for effective chemotherapy of liver cancer
title_full Low density lipoprotein modified silica nanoparticles loaded with docetaxel and thalidomide for effective chemotherapy of liver cancer
title_fullStr Low density lipoprotein modified silica nanoparticles loaded with docetaxel and thalidomide for effective chemotherapy of liver cancer
title_full_unstemmed Low density lipoprotein modified silica nanoparticles loaded with docetaxel and thalidomide for effective chemotherapy of liver cancer
title_short Low density lipoprotein modified silica nanoparticles loaded with docetaxel and thalidomide for effective chemotherapy of liver cancer
title_sort low density lipoprotein modified silica nanoparticles loaded with docetaxel and thalidomide for effective chemotherapy of liver cancer
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912100/
https://www.ncbi.nlm.nih.gov/pubmed/29513882
http://dx.doi.org/10.1590/1414-431X20176650
work_keys_str_mv AT aoman lowdensitylipoproteinmodifiedsilicananoparticlesloadedwithdocetaxelandthalidomideforeffectivechemotherapyoflivercancer
AT xiaoxu lowdensitylipoproteinmodifiedsilicananoparticlesloadedwithdocetaxelandthalidomideforeffectivechemotherapyoflivercancer
AT aoyazhou lowdensitylipoproteinmodifiedsilicananoparticlesloadedwithdocetaxelandthalidomideforeffectivechemotherapyoflivercancer

Ejemplares similares