Cargando…

Insulin resistance and coronary artery disease in non-diabetic patients: Is there any correlation?

BACKGROUND: Cardiovascular diseases are the most common causes of death in the world and type 2 diabetes is one of them because it is highly prevalent and doubles heart disease risk. Some studies suggest that insulin resistance is associated with coronary artery disease in non-diabetics. The aim of...

Descripción completa

Detalles Bibliográficos
Autores principales: Vafaeimanesh, Jamshid, Parham, Mahmoud, Norouzi, Samieh, Hamednasimi, Parinaz, Bagherzadeh, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Babol University of Medical Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912218/
https://www.ncbi.nlm.nih.gov/pubmed/29732028
http://dx.doi.org/10.22088/cjim.9.2.121
_version_ 1783316352326434816
author Vafaeimanesh, Jamshid
Parham, Mahmoud
Norouzi, Samieh
Hamednasimi, Parinaz
Bagherzadeh, Mohammad
author_facet Vafaeimanesh, Jamshid
Parham, Mahmoud
Norouzi, Samieh
Hamednasimi, Parinaz
Bagherzadeh, Mohammad
author_sort Vafaeimanesh, Jamshid
collection PubMed
description BACKGROUND: Cardiovascular diseases are the most common causes of death in the world and type 2 diabetes is one of them because it is highly prevalent and doubles heart disease risk. Some studies suggest that insulin resistance is associated with coronary artery disease in non-diabetics. The aim of this study was to evaluate the association of insulin resistance (IR) and coronary artery disease (CAD) in non-diabetic patients. METHODS: In this cross-sectional study, from September 2014 to July 2015, 120 patients referring to Shahid Beheshti Hospital of Qom were evaluated. Their medical history, baseline laboratory studies, BMI and GFR were recorded. After 8 hours of fasting, blood samples were taken from the patients at 8 am, including fasting glucose and insulin level. We estimated insulin resistance using the homeostatic model assessment index of IR (HOMA-IR). Finally, we evaluated the association between IR and CAD. RESULTS: Totally, 120 patients were assigned to participate in this study, among them, 50 patients without CAD and 70 with coronary artery stenosis. Insulin resistance (HOMA-IR> 2.5) was positive in 59 (49.3%) patients and negative in 61 (50.7%) patients. Hence, the correlation between IR and CAD was not statistically significant (P=0.9). CONCLUSIONS: In this study, although the correlation was not found between insulin resistance and coronary heart disease, among men, we found a significant association between coronary heart disease and insulin resistance.
format Online
Article
Text
id pubmed-5912218
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Babol University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-59122182018-05-04 Insulin resistance and coronary artery disease in non-diabetic patients: Is there any correlation? Vafaeimanesh, Jamshid Parham, Mahmoud Norouzi, Samieh Hamednasimi, Parinaz Bagherzadeh, Mohammad Caspian J Intern Med Original Article BACKGROUND: Cardiovascular diseases are the most common causes of death in the world and type 2 diabetes is one of them because it is highly prevalent and doubles heart disease risk. Some studies suggest that insulin resistance is associated with coronary artery disease in non-diabetics. The aim of this study was to evaluate the association of insulin resistance (IR) and coronary artery disease (CAD) in non-diabetic patients. METHODS: In this cross-sectional study, from September 2014 to July 2015, 120 patients referring to Shahid Beheshti Hospital of Qom were evaluated. Their medical history, baseline laboratory studies, BMI and GFR were recorded. After 8 hours of fasting, blood samples were taken from the patients at 8 am, including fasting glucose and insulin level. We estimated insulin resistance using the homeostatic model assessment index of IR (HOMA-IR). Finally, we evaluated the association between IR and CAD. RESULTS: Totally, 120 patients were assigned to participate in this study, among them, 50 patients without CAD and 70 with coronary artery stenosis. Insulin resistance (HOMA-IR> 2.5) was positive in 59 (49.3%) patients and negative in 61 (50.7%) patients. Hence, the correlation between IR and CAD was not statistically significant (P=0.9). CONCLUSIONS: In this study, although the correlation was not found between insulin resistance and coronary heart disease, among men, we found a significant association between coronary heart disease and insulin resistance. Babol University of Medical Sciences 2018 /pmc/articles/PMC5912218/ /pubmed/29732028 http://dx.doi.org/10.22088/cjim.9.2.121 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Vafaeimanesh, Jamshid
Parham, Mahmoud
Norouzi, Samieh
Hamednasimi, Parinaz
Bagherzadeh, Mohammad
Insulin resistance and coronary artery disease in non-diabetic patients: Is there any correlation?
title Insulin resistance and coronary artery disease in non-diabetic patients: Is there any correlation?
title_full Insulin resistance and coronary artery disease in non-diabetic patients: Is there any correlation?
title_fullStr Insulin resistance and coronary artery disease in non-diabetic patients: Is there any correlation?
title_full_unstemmed Insulin resistance and coronary artery disease in non-diabetic patients: Is there any correlation?
title_short Insulin resistance and coronary artery disease in non-diabetic patients: Is there any correlation?
title_sort insulin resistance and coronary artery disease in non-diabetic patients: is there any correlation?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912218/
https://www.ncbi.nlm.nih.gov/pubmed/29732028
http://dx.doi.org/10.22088/cjim.9.2.121
work_keys_str_mv AT vafaeimaneshjamshid insulinresistanceandcoronaryarterydiseaseinnondiabeticpatientsisthereanycorrelation
AT parhammahmoud insulinresistanceandcoronaryarterydiseaseinnondiabeticpatientsisthereanycorrelation
AT norouzisamieh insulinresistanceandcoronaryarterydiseaseinnondiabeticpatientsisthereanycorrelation
AT hamednasimiparinaz insulinresistanceandcoronaryarterydiseaseinnondiabeticpatientsisthereanycorrelation
AT bagherzadehmohammad insulinresistanceandcoronaryarterydiseaseinnondiabeticpatientsisthereanycorrelation