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Prevalence and severity of ocular involvement in Graves’ disease according to sex and age: A clinical study from Babol, Iran

BACKGROUND: Thyroid-associated eye disease (TED), previously known as Graves’ ophthalmopathy is a cosmetically and functionally debilitating disease that is seen worldwide. The aim of this study was to evaluate the prevalence and clinical severity of ocular manifestations of Graves’ disease accordin...

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Autores principales: Gharib, Sara, Moazezi, Zoleika, Bayani, Mohammad Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Babol University of Medical Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912227/
https://www.ncbi.nlm.nih.gov/pubmed/29732037
http://dx.doi.org/10.22088/cjim.9.2.178
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author Gharib, Sara
Moazezi, Zoleika
Bayani, Mohammad Ali
author_facet Gharib, Sara
Moazezi, Zoleika
Bayani, Mohammad Ali
author_sort Gharib, Sara
collection PubMed
description BACKGROUND: Thyroid-associated eye disease (TED), previously known as Graves’ ophthalmopathy is a cosmetically and functionally debilitating disease that is seen worldwide. The aim of this study was to evaluate the prevalence and clinical severity of ocular manifestations of Graves’ disease according to sex, age and duration in northern Iran. METHODS: Between April 2011 and March 2012, 105 patients with Graves’ disease, underwent ophthalmic examination, including ocular motility, exophthalmometry, intraocular pressure (IOP), slit lamp and fundoscopy. Patients received scores according to modified Werner’s NO SPECS classification. RESULTS: Ocular involvement was found in 70 patients with established Graves’s disease. The mean age was 35.0 years, (SD 13.0, range 15 to 69). The most common ocular findings were exophthalmometric proptosis of more than 20 mm (63.8%), lid lag (55.7%), lid retraction (52.8%) and tearing (38.6%). Almost 70% of patients had bilateral involvement. Elevated IOP was seen in 15 (25.4%) patients, and was significantly related to proptosis (P=0.007). More than half of the patients (n=36, 52.2%) had a modified Werner’s NO SPECS score of 3.00. Clinical severity as shown by the increasing number of signs and symptoms per patient was correlated to increasing age (r=0.31, P=0.01) but not to gender (P=0.17). CONCLUSIONS: Both functional (ocular motility disorders, increased IOP) and cosmetic (proptosis, periorbital edema) sequels are common ocular presentations in patients with Graves' disease. Proptosis was the most common finding in this study and was associated with elevated IOP. Clinical severity was found to correlate to increasing age.
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spelling pubmed-59122272018-05-04 Prevalence and severity of ocular involvement in Graves’ disease according to sex and age: A clinical study from Babol, Iran Gharib, Sara Moazezi, Zoleika Bayani, Mohammad Ali Caspian J Intern Med Original Article BACKGROUND: Thyroid-associated eye disease (TED), previously known as Graves’ ophthalmopathy is a cosmetically and functionally debilitating disease that is seen worldwide. The aim of this study was to evaluate the prevalence and clinical severity of ocular manifestations of Graves’ disease according to sex, age and duration in northern Iran. METHODS: Between April 2011 and March 2012, 105 patients with Graves’ disease, underwent ophthalmic examination, including ocular motility, exophthalmometry, intraocular pressure (IOP), slit lamp and fundoscopy. Patients received scores according to modified Werner’s NO SPECS classification. RESULTS: Ocular involvement was found in 70 patients with established Graves’s disease. The mean age was 35.0 years, (SD 13.0, range 15 to 69). The most common ocular findings were exophthalmometric proptosis of more than 20 mm (63.8%), lid lag (55.7%), lid retraction (52.8%) and tearing (38.6%). Almost 70% of patients had bilateral involvement. Elevated IOP was seen in 15 (25.4%) patients, and was significantly related to proptosis (P=0.007). More than half of the patients (n=36, 52.2%) had a modified Werner’s NO SPECS score of 3.00. Clinical severity as shown by the increasing number of signs and symptoms per patient was correlated to increasing age (r=0.31, P=0.01) but not to gender (P=0.17). CONCLUSIONS: Both functional (ocular motility disorders, increased IOP) and cosmetic (proptosis, periorbital edema) sequels are common ocular presentations in patients with Graves' disease. Proptosis was the most common finding in this study and was associated with elevated IOP. Clinical severity was found to correlate to increasing age. Babol University of Medical Sciences 2018 /pmc/articles/PMC5912227/ /pubmed/29732037 http://dx.doi.org/10.22088/cjim.9.2.178 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Gharib, Sara
Moazezi, Zoleika
Bayani, Mohammad Ali
Prevalence and severity of ocular involvement in Graves’ disease according to sex and age: A clinical study from Babol, Iran
title Prevalence and severity of ocular involvement in Graves’ disease according to sex and age: A clinical study from Babol, Iran
title_full Prevalence and severity of ocular involvement in Graves’ disease according to sex and age: A clinical study from Babol, Iran
title_fullStr Prevalence and severity of ocular involvement in Graves’ disease according to sex and age: A clinical study from Babol, Iran
title_full_unstemmed Prevalence and severity of ocular involvement in Graves’ disease according to sex and age: A clinical study from Babol, Iran
title_short Prevalence and severity of ocular involvement in Graves’ disease according to sex and age: A clinical study from Babol, Iran
title_sort prevalence and severity of ocular involvement in graves’ disease according to sex and age: a clinical study from babol, iran
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912227/
https://www.ncbi.nlm.nih.gov/pubmed/29732037
http://dx.doi.org/10.22088/cjim.9.2.178
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