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Prophylactic function of excellent compliance with LTOT in the development of pulmonary hypertension due to COPD with hypoxemia

The long-term oxygen therapy (LTOT) for patients with chronic obstructive pulmonary disease (COPD) has been shown to increase survival in patients with severe resting hypoxemia. The adherence to LTOT may also simultaneously affect the development of concomitant pulmonary hypertension (PH) due to COP...

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Autores principales: Xiong, Wei, Zhao, Yunfeng, Gong, Sugang, Zhao, Qinhua, Liu, Jinming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912280/
https://www.ncbi.nlm.nih.gov/pubmed/29493384
http://dx.doi.org/10.1177/2045894018765835
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author Xiong, Wei
Zhao, Yunfeng
Gong, Sugang
Zhao, Qinhua
Liu, Jinming
author_facet Xiong, Wei
Zhao, Yunfeng
Gong, Sugang
Zhao, Qinhua
Liu, Jinming
author_sort Xiong, Wei
collection PubMed
description The long-term oxygen therapy (LTOT) for patients with chronic obstructive pulmonary disease (COPD) has been shown to increase survival in patients with severe resting hypoxemia. The adherence to LTOT may also simultaneously affect the development of concomitant pulmonary hypertension (PH) due to COPD with hypoxemia. We retrospectively reviewed 276 cases of COPD with or without PH assessed by right heart catheterization (RHC) to investigate whether adherence to continuous LTOT had a prophylactic effect on the development of PH in a time interval of two years. In contrast to the patients in the non-compliance group (PH prevalence 64.2%), patients with excellent compliance of adhering to continuous LTOT > 15 h per day in the compliance group (PH prevalence 37.6%) are more liable to postpone the development of PH due to hypoxic COPD for at least two years. Adherence to LTOT ≥ 15 h/day is strongly recommended in order to lower the risk and delay the development of consequent PH in COPD with hypoxemia.
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spelling pubmed-59122802018-04-27 Prophylactic function of excellent compliance with LTOT in the development of pulmonary hypertension due to COPD with hypoxemia Xiong, Wei Zhao, Yunfeng Gong, Sugang Zhao, Qinhua Liu, Jinming Pulm Circ Research Article The long-term oxygen therapy (LTOT) for patients with chronic obstructive pulmonary disease (COPD) has been shown to increase survival in patients with severe resting hypoxemia. The adherence to LTOT may also simultaneously affect the development of concomitant pulmonary hypertension (PH) due to COPD with hypoxemia. We retrospectively reviewed 276 cases of COPD with or without PH assessed by right heart catheterization (RHC) to investigate whether adherence to continuous LTOT had a prophylactic effect on the development of PH in a time interval of two years. In contrast to the patients in the non-compliance group (PH prevalence 64.2%), patients with excellent compliance of adhering to continuous LTOT > 15 h per day in the compliance group (PH prevalence 37.6%) are more liable to postpone the development of PH due to hypoxic COPD for at least two years. Adherence to LTOT ≥ 15 h/day is strongly recommended in order to lower the risk and delay the development of consequent PH in COPD with hypoxemia. SAGE Publications 2018-03-01 /pmc/articles/PMC5912280/ /pubmed/29493384 http://dx.doi.org/10.1177/2045894018765835 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Article
Xiong, Wei
Zhao, Yunfeng
Gong, Sugang
Zhao, Qinhua
Liu, Jinming
Prophylactic function of excellent compliance with LTOT in the development of pulmonary hypertension due to COPD with hypoxemia
title Prophylactic function of excellent compliance with LTOT in the development of pulmonary hypertension due to COPD with hypoxemia
title_full Prophylactic function of excellent compliance with LTOT in the development of pulmonary hypertension due to COPD with hypoxemia
title_fullStr Prophylactic function of excellent compliance with LTOT in the development of pulmonary hypertension due to COPD with hypoxemia
title_full_unstemmed Prophylactic function of excellent compliance with LTOT in the development of pulmonary hypertension due to COPD with hypoxemia
title_short Prophylactic function of excellent compliance with LTOT in the development of pulmonary hypertension due to COPD with hypoxemia
title_sort prophylactic function of excellent compliance with ltot in the development of pulmonary hypertension due to copd with hypoxemia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912280/
https://www.ncbi.nlm.nih.gov/pubmed/29493384
http://dx.doi.org/10.1177/2045894018765835
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