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Association Between Vitamin D Insufficiency and Metabolic Syndrome in Patients With Psychotic Disorders

OBJECTIVE: This study examined the association between vitamin D and metabolic syndrome in patients with psychotic disorders. METHODS: The study enrolled 302 community-dwelling patients with psychotic disorders. Sociodemographic and clinical characteristics, including blood pressure, physical activi...

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Autores principales: Yoo, Taeyoung, Choi, Wonsuk, Hong, Jin-Hee, Lee, Ju-Yeon, Kim, Jae-Min, Shin, Il-Seon, Yang, Soo Jin, Amminger, Paul, Berk, Michael, Yoon, Jin-Sang, Kim, Sung-Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neuropsychiatric Association 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912492/
https://www.ncbi.nlm.nih.gov/pubmed/29486549
http://dx.doi.org/10.30773/pi.2017.08.30
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author Yoo, Taeyoung
Choi, Wonsuk
Hong, Jin-Hee
Lee, Ju-Yeon
Kim, Jae-Min
Shin, Il-Seon
Yang, Soo Jin
Amminger, Paul
Berk, Michael
Yoon, Jin-Sang
Kim, Sung-Wan
author_facet Yoo, Taeyoung
Choi, Wonsuk
Hong, Jin-Hee
Lee, Ju-Yeon
Kim, Jae-Min
Shin, Il-Seon
Yang, Soo Jin
Amminger, Paul
Berk, Michael
Yoon, Jin-Sang
Kim, Sung-Wan
author_sort Yoo, Taeyoung
collection PubMed
description OBJECTIVE: This study examined the association between vitamin D and metabolic syndrome in patients with psychotic disorders. METHODS: The study enrolled 302 community-dwelling patients with psychotic disorders. Sociodemographic and clinical characteristics, including blood pressure, physical activity, and dietary habit were gathered. Laboratory examinations included vitamin D, lipid profile, fasting plasma glucose, HbA1c, liver function, and renal function. Vitamin D insufficiency was defined as <20 ng/mL. Clinical characteristics associated with vitamin D insufficiency were identified. RESULTS: Among the 302 participants, 236 patients (78.1%) had a vitamin D insufficiency and 97 (32.1%) had metabolic syndrome. Vitamin D insufficiency was significantly associated with the presence of metabolic syndrome (p=0.006) and hypertension (p=0.017). Significant increases in triglycerides and alanine transaminase were observed in the group with a vitamin D insufficiency (p=0.002 and 0.011, respectively). After adjusting for physical activity and dietary habit scores, vitamin D insufficiency remained significantly associated with metabolic syndrome and hypertension. CONCLUSION: Vitamin D insufficiency was associated with metabolic syndrome and was particularly associated with high blood pressure, although the nature, direction and implications of this association are unclear.
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spelling pubmed-59124922018-04-30 Association Between Vitamin D Insufficiency and Metabolic Syndrome in Patients With Psychotic Disorders Yoo, Taeyoung Choi, Wonsuk Hong, Jin-Hee Lee, Ju-Yeon Kim, Jae-Min Shin, Il-Seon Yang, Soo Jin Amminger, Paul Berk, Michael Yoon, Jin-Sang Kim, Sung-Wan Psychiatry Investig Original Article OBJECTIVE: This study examined the association between vitamin D and metabolic syndrome in patients with psychotic disorders. METHODS: The study enrolled 302 community-dwelling patients with psychotic disorders. Sociodemographic and clinical characteristics, including blood pressure, physical activity, and dietary habit were gathered. Laboratory examinations included vitamin D, lipid profile, fasting plasma glucose, HbA1c, liver function, and renal function. Vitamin D insufficiency was defined as <20 ng/mL. Clinical characteristics associated with vitamin D insufficiency were identified. RESULTS: Among the 302 participants, 236 patients (78.1%) had a vitamin D insufficiency and 97 (32.1%) had metabolic syndrome. Vitamin D insufficiency was significantly associated with the presence of metabolic syndrome (p=0.006) and hypertension (p=0.017). Significant increases in triglycerides and alanine transaminase were observed in the group with a vitamin D insufficiency (p=0.002 and 0.011, respectively). After adjusting for physical activity and dietary habit scores, vitamin D insufficiency remained significantly associated with metabolic syndrome and hypertension. CONCLUSION: Vitamin D insufficiency was associated with metabolic syndrome and was particularly associated with high blood pressure, although the nature, direction and implications of this association are unclear. Korean Neuropsychiatric Association 2018-04 2018-02-28 /pmc/articles/PMC5912492/ /pubmed/29486549 http://dx.doi.org/10.30773/pi.2017.08.30 Text en Copyright © 2018 Korean Neuropsychiatric Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yoo, Taeyoung
Choi, Wonsuk
Hong, Jin-Hee
Lee, Ju-Yeon
Kim, Jae-Min
Shin, Il-Seon
Yang, Soo Jin
Amminger, Paul
Berk, Michael
Yoon, Jin-Sang
Kim, Sung-Wan
Association Between Vitamin D Insufficiency and Metabolic Syndrome in Patients With Psychotic Disorders
title Association Between Vitamin D Insufficiency and Metabolic Syndrome in Patients With Psychotic Disorders
title_full Association Between Vitamin D Insufficiency and Metabolic Syndrome in Patients With Psychotic Disorders
title_fullStr Association Between Vitamin D Insufficiency and Metabolic Syndrome in Patients With Psychotic Disorders
title_full_unstemmed Association Between Vitamin D Insufficiency and Metabolic Syndrome in Patients With Psychotic Disorders
title_short Association Between Vitamin D Insufficiency and Metabolic Syndrome in Patients With Psychotic Disorders
title_sort association between vitamin d insufficiency and metabolic syndrome in patients with psychotic disorders
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912492/
https://www.ncbi.nlm.nih.gov/pubmed/29486549
http://dx.doi.org/10.30773/pi.2017.08.30
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