A Functional Polymorphism in the DRD1 Gene, That Modulates Its Regulation by miR-504, Is Associated with Depressive Symptoms

OBJECTIVE: The aim of this study was to examine a possible association between depressive symptoms and a functional polymorphism (rs686) that modulates the regulation of DRD1 gene by miR-504. METHODS: A total of 239 young Colombian subjects were evaluated with the Patient Health Questionnaire-9 (PHQ...

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Detalles Bibliográficos
Autores principales: Jiménez, Karen M., Pereira-Morales, Angela J., Forero, Diego A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neuropsychiatric Association 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912498/
https://www.ncbi.nlm.nih.gov/pubmed/29614853
http://dx.doi.org/10.30773/pi.2017.10.16.1
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author Jiménez, Karen M.
Pereira-Morales, Angela J.
Forero, Diego A.
author_facet Jiménez, Karen M.
Pereira-Morales, Angela J.
Forero, Diego A.
author_sort Jiménez, Karen M.
collection PubMed
description OBJECTIVE: The aim of this study was to examine a possible association between depressive symptoms and a functional polymorphism (rs686) that modulates the regulation of DRD1 gene by miR-504. METHODS: A total of 239 young Colombian subjects were evaluated with the Patient Health Questionnaire-9 (PHQ-9) scale and genotyped for the rs686 polymorphism. A linear regression model, corrected by age and gender, was used. RESULTS: A significant association between the rs686 polymorphism and PHQ-9 scores was found, under a dominant genetic model (p=0.0094). CONCLUSION: These results provide novel evidence about the growing role of inherited variants in binding sites for brain-expressed miRNAs on depressive symptomatology.
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spelling pubmed-59124982018-04-30 A Functional Polymorphism in the DRD1 Gene, That Modulates Its Regulation by miR-504, Is Associated with Depressive Symptoms Jiménez, Karen M. Pereira-Morales, Angela J. Forero, Diego A. Psychiatry Investig Original Article OBJECTIVE: The aim of this study was to examine a possible association between depressive symptoms and a functional polymorphism (rs686) that modulates the regulation of DRD1 gene by miR-504. METHODS: A total of 239 young Colombian subjects were evaluated with the Patient Health Questionnaire-9 (PHQ-9) scale and genotyped for the rs686 polymorphism. A linear regression model, corrected by age and gender, was used. RESULTS: A significant association between the rs686 polymorphism and PHQ-9 scores was found, under a dominant genetic model (p=0.0094). CONCLUSION: These results provide novel evidence about the growing role of inherited variants in binding sites for brain-expressed miRNAs on depressive symptomatology. Korean Neuropsychiatric Association 2018-04 2018-04-05 /pmc/articles/PMC5912498/ /pubmed/29614853 http://dx.doi.org/10.30773/pi.2017.10.16.1 Text en Copyright © 2018 Korean Neuropsychiatric Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jiménez, Karen M.
Pereira-Morales, Angela J.
Forero, Diego A.
A Functional Polymorphism in the DRD1 Gene, That Modulates Its Regulation by miR-504, Is Associated with Depressive Symptoms
title A Functional Polymorphism in the DRD1 Gene, That Modulates Its Regulation by miR-504, Is Associated with Depressive Symptoms
title_full A Functional Polymorphism in the DRD1 Gene, That Modulates Its Regulation by miR-504, Is Associated with Depressive Symptoms
title_fullStr A Functional Polymorphism in the DRD1 Gene, That Modulates Its Regulation by miR-504, Is Associated with Depressive Symptoms
title_full_unstemmed A Functional Polymorphism in the DRD1 Gene, That Modulates Its Regulation by miR-504, Is Associated with Depressive Symptoms
title_short A Functional Polymorphism in the DRD1 Gene, That Modulates Its Regulation by miR-504, Is Associated with Depressive Symptoms
title_sort functional polymorphism in the drd1 gene, that modulates its regulation by mir-504, is associated with depressive symptoms
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912498/
https://www.ncbi.nlm.nih.gov/pubmed/29614853
http://dx.doi.org/10.30773/pi.2017.10.16.1
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