Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib

Tenovin-6 is the most studied member of a family of small molecules with antitumour activity in vivo. Previously, it has been determined that part of the effects of tenovin-6 associate with its ability to inhibit SirT1 and activate p53. However, tenovin-6 has also been shown to modulate autophagic f...

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Detalles Bibliográficos
Autores principales: Ladds, Marcus J. G. W., Pastor-Fernández, Andrés, Popova, Gergana, van Leeuwen, Ingeborg M. M., Eng, Kai Er, Drummond, Catherine J., Johansson, Lars, Svensson, Richard, Westwood, Nicholas J., McCarthy, Anna R., Tholander, Fredrik, Popa, Mihaela, Lane, David P., McCormack, Emmet, McInerney, Gerald M., Bhatia, Ravi, Laín, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912769/
https://www.ncbi.nlm.nih.gov/pubmed/29684045
http://dx.doi.org/10.1371/journal.pone.0195956

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