Chromatin accessibility is associated with CRISPR-Cas9 efficiency in the zebrafish (Danio rerio)

CRISPR-Cas9 technology is routinely applied for targeted mutagenesis in model organisms and cell lines. Recent studies indicate that the prokaryotic CRISPR-Cas9 system is affected by eukaryotic chromatin structures. Here, we show that the likelihood of successful mutagenesis correlates with transcri...

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Detalles Bibliográficos
Autores principales: Uusi-Mäkelä, Meri I. E., Barker, Harlan R., Bäuerlein, Carina A., Häkkinen, Tomi, Nykter, Matti, Rämet, Mika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912780/
https://www.ncbi.nlm.nih.gov/pubmed/29684067
http://dx.doi.org/10.1371/journal.pone.0196238

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