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Subcortical and cortical morphological anomalies as an endophenotype in Obsessive-Compulsive Disorder

Endophentoypes, quantifiable traits lying on the causal chain between a clinical phenotype and etiology, can be used to accelerate genomic discovery in Obsessive-Compulsive Disorder (OCD). Here we identify the neuroanatomic changes that are shared by 22 OCD adult and adolescent patients and 25 of th...

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Autores principales: Shaw, Philip, Sharp, Wendy, Sudre, Gustavo, Wharton, Amy, Greenstein, Deanna, Chakravarty, M. Mallar, Lerch, Jason P., Rapoport, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912882/
https://www.ncbi.nlm.nih.gov/pubmed/24514568
http://dx.doi.org/10.1038/mp.2014.3
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author Shaw, Philip
Sharp, Wendy
Sudre, Gustavo
Wharton, Amy
Greenstein, Deanna
Chakravarty, M. Mallar
Lerch, Jason P.
Rapoport, Judith
author_facet Shaw, Philip
Sharp, Wendy
Sudre, Gustavo
Wharton, Amy
Greenstein, Deanna
Chakravarty, M. Mallar
Lerch, Jason P.
Rapoport, Judith
author_sort Shaw, Philip
collection PubMed
description Endophentoypes, quantifiable traits lying on the causal chain between a clinical phenotype and etiology, can be used to accelerate genomic discovery in Obsessive-Compulsive Disorder (OCD). Here we identify the neuroanatomic changes that are shared by 22 OCD adult and adolescent patients and 25 of their unaffected siblings who are at genetic risk for the disorder. Comparisons were made against 47 age and sex matched healthy controls. We defined the surface morphology of the striatum, globus pallidus and thalamus, and thickness of the cerebral cortex. Patients with OCD show significant surface expansion compared to healthy controls, following adjustment for multiple comparisons, in interconnected regions of the caudate, thalamus and right orbitofrontal cortex. Their unaffected siblings show similar, significant expansion, most marked in the ventromedial caudate bilaterally, the right pulvinar thalamic nucleus and the right orbitofrontal cortex. These regions define a network that has been consistently implicated in OCD. Additionally both patients with OCD and unaffected siblings showed similar increased thickness of the right precuneus which receives rich input from the thalamic pulvinar nuclei and the left medial temporal cortex. Anatomic change within the orbitofrontostriatal and posterior brain circuitry thus emerges as a promising endophenotype for OCD.
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spelling pubmed-59128822018-04-23 Subcortical and cortical morphological anomalies as an endophenotype in Obsessive-Compulsive Disorder Shaw, Philip Sharp, Wendy Sudre, Gustavo Wharton, Amy Greenstein, Deanna Chakravarty, M. Mallar Lerch, Jason P. Rapoport, Judith Mol Psychiatry Article Endophentoypes, quantifiable traits lying on the causal chain between a clinical phenotype and etiology, can be used to accelerate genomic discovery in Obsessive-Compulsive Disorder (OCD). Here we identify the neuroanatomic changes that are shared by 22 OCD adult and adolescent patients and 25 of their unaffected siblings who are at genetic risk for the disorder. Comparisons were made against 47 age and sex matched healthy controls. We defined the surface morphology of the striatum, globus pallidus and thalamus, and thickness of the cerebral cortex. Patients with OCD show significant surface expansion compared to healthy controls, following adjustment for multiple comparisons, in interconnected regions of the caudate, thalamus and right orbitofrontal cortex. Their unaffected siblings show similar, significant expansion, most marked in the ventromedial caudate bilaterally, the right pulvinar thalamic nucleus and the right orbitofrontal cortex. These regions define a network that has been consistently implicated in OCD. Additionally both patients with OCD and unaffected siblings showed similar increased thickness of the right precuneus which receives rich input from the thalamic pulvinar nuclei and the left medial temporal cortex. Anatomic change within the orbitofrontostriatal and posterior brain circuitry thus emerges as a promising endophenotype for OCD. 2014-02-11 2015-02 /pmc/articles/PMC5912882/ /pubmed/24514568 http://dx.doi.org/10.1038/mp.2014.3 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Shaw, Philip
Sharp, Wendy
Sudre, Gustavo
Wharton, Amy
Greenstein, Deanna
Chakravarty, M. Mallar
Lerch, Jason P.
Rapoport, Judith
Subcortical and cortical morphological anomalies as an endophenotype in Obsessive-Compulsive Disorder
title Subcortical and cortical morphological anomalies as an endophenotype in Obsessive-Compulsive Disorder
title_full Subcortical and cortical morphological anomalies as an endophenotype in Obsessive-Compulsive Disorder
title_fullStr Subcortical and cortical morphological anomalies as an endophenotype in Obsessive-Compulsive Disorder
title_full_unstemmed Subcortical and cortical morphological anomalies as an endophenotype in Obsessive-Compulsive Disorder
title_short Subcortical and cortical morphological anomalies as an endophenotype in Obsessive-Compulsive Disorder
title_sort subcortical and cortical morphological anomalies as an endophenotype in obsessive-compulsive disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912882/
https://www.ncbi.nlm.nih.gov/pubmed/24514568
http://dx.doi.org/10.1038/mp.2014.3
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