A zebrafish and mouse model for selective pruritus via direct activation of TRPA1

Little is known about the capacity of lower vertebrates to experience itch. A screen of itch-inducing compounds (pruritogens) in zebrafish larvae yielded a single pruritogen, the TLR7 agonist imiquimod, that elicited a somatosensory neuron response. Imiquimod induced itch-like behaviors in zebrafish...

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Detalles Bibliográficos
Autores principales: Esancy, Kali, Condon, Logan, Feng, Jing, Kimball, Corinna, Curtright, Andrew, Dhaka, Ajay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912907/
https://www.ncbi.nlm.nih.gov/pubmed/29561265
http://dx.doi.org/10.7554/eLife.32036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912907/
https://www.ncbi.nlm.nih.gov/pubmed/29561265
http://dx.doi.org/10.7554/eLife.32036

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