RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment

Physical exercise in combination with cognitive training is known to enhance synaptic plasticity, learning, and memory and lower the risk for various complex diseases including Alzheimer’s disease. Here, we show that exposure of adult male mice to an environmental enrichment paradigm leads to enhanc...

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Detalles Bibliográficos
Autores principales: Benito, Eva, Kerimoglu, Cemil, Ramachandran, Binu, Pena-Centeno, Tonatiuh, Jain, Gaurav, Stilling, Roman Manuel, Islam, Md Rezaul, Capece, Vincenzo, Zhou, Qihui, Edbauer, Dieter, Dean, Camin, Fischer, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912949/
https://www.ncbi.nlm.nih.gov/pubmed/29642011
http://dx.doi.org/10.1016/j.celrep.2018.03.059
Descripción
Sumario:Physical exercise in combination with cognitive training is known to enhance synaptic plasticity, learning, and memory and lower the risk for various complex diseases including Alzheimer’s disease. Here, we show that exposure of adult male mice to an environmental enrichment paradigm leads to enhancement of synaptic plasticity and cognition also in the next generation. We show that this effect is mediated through sperm RNA and especially miRs 212/132. In conclusion, our study reports intergenerational inheritance of an acquired cognitive benefit and points to specific miRs as candidates mechanistically involved in this type of transmission.

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