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RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment
Physical exercise in combination with cognitive training is known to enhance synaptic plasticity, learning, and memory and lower the risk for various complex diseases including Alzheimer’s disease. Here, we show that exposure of adult male mice to an environmental enrichment paradigm leads to enhanc...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912949/ https://www.ncbi.nlm.nih.gov/pubmed/29642011 http://dx.doi.org/10.1016/j.celrep.2018.03.059 |
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| author | Benito, Eva Kerimoglu, Cemil Ramachandran, Binu Pena-Centeno, Tonatiuh Jain, Gaurav Stilling, Roman Manuel Islam, Md Rezaul Capece, Vincenzo Zhou, Qihui Edbauer, Dieter Dean, Camin Fischer, André |
| author_facet | Benito, Eva Kerimoglu, Cemil Ramachandran, Binu Pena-Centeno, Tonatiuh Jain, Gaurav Stilling, Roman Manuel Islam, Md Rezaul Capece, Vincenzo Zhou, Qihui Edbauer, Dieter Dean, Camin Fischer, André |
| author_sort | Benito, Eva |
| collection | PubMed |
| description | Physical exercise in combination with cognitive training is known to enhance synaptic plasticity, learning, and memory and lower the risk for various complex diseases including Alzheimer’s disease. Here, we show that exposure of adult male mice to an environmental enrichment paradigm leads to enhancement of synaptic plasticity and cognition also in the next generation. We show that this effect is mediated through sperm RNA and especially miRs 212/132. In conclusion, our study reports intergenerational inheritance of an acquired cognitive benefit and points to specific miRs as candidates mechanistically involved in this type of transmission. |
| format | Online Article Text |
| id | pubmed-5912949 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Cell Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-59129492018-04-27 RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment Benito, Eva Kerimoglu, Cemil Ramachandran, Binu Pena-Centeno, Tonatiuh Jain, Gaurav Stilling, Roman Manuel Islam, Md Rezaul Capece, Vincenzo Zhou, Qihui Edbauer, Dieter Dean, Camin Fischer, André Cell Rep Article Physical exercise in combination with cognitive training is known to enhance synaptic plasticity, learning, and memory and lower the risk for various complex diseases including Alzheimer’s disease. Here, we show that exposure of adult male mice to an environmental enrichment paradigm leads to enhancement of synaptic plasticity and cognition also in the next generation. We show that this effect is mediated through sperm RNA and especially miRs 212/132. In conclusion, our study reports intergenerational inheritance of an acquired cognitive benefit and points to specific miRs as candidates mechanistically involved in this type of transmission. Cell Press 2018-04-10 /pmc/articles/PMC5912949/ /pubmed/29642011 http://dx.doi.org/10.1016/j.celrep.2018.03.059 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Benito, Eva Kerimoglu, Cemil Ramachandran, Binu Pena-Centeno, Tonatiuh Jain, Gaurav Stilling, Roman Manuel Islam, Md Rezaul Capece, Vincenzo Zhou, Qihui Edbauer, Dieter Dean, Camin Fischer, André RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment |
| title | RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment |
| title_full | RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment |
| title_fullStr | RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment |
| title_full_unstemmed | RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment |
| title_short | RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment |
| title_sort | rna-dependent intergenerational inheritance of enhanced synaptic plasticity after environmental enrichment |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912949/ https://www.ncbi.nlm.nih.gov/pubmed/29642011 http://dx.doi.org/10.1016/j.celrep.2018.03.059 |
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