Xylanilyticolides A–C, Three New Compounds from Cultures of the Actinomycete Promicromonospora xylanilytica YIM 61515

ABSTRACT: Three new lactones, xylanilyticolides A–C (1–3), were isolated from cultures of the actinomycete Promicromonospora xylanilytica YIM 61515. Their structures were elucidated by 1D and 2D NMR spectroscopic data in conjunction with HRESIMS analysis. Compound 1 exhibited potent cytotoxicities a...

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Detalles Bibliográficos
Autores principales: Wang, Zhen-Xiong, Qin, Shen, Xu, Li-Hua, Chen, He-Ping, Sun, Huan, Huang, Rong, Li, Zheng-Hui, Feng, Tao, Liu, Ji-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913047/
https://www.ncbi.nlm.nih.gov/pubmed/29441465
http://dx.doi.org/10.1007/s13659-018-0154-1
Descripción
Sumario:ABSTRACT: Three new lactones, xylanilyticolides A–C (1–3), were isolated from cultures of the actinomycete Promicromonospora xylanilytica YIM 61515. Their structures were elucidated by 1D and 2D NMR spectroscopic data in conjunction with HRESIMS analysis. Compound 1 exhibited potent cytotoxicities against five human cancer cell lines HL-60, A-549, SMMC-7721, MCF-7 and SW480 with the IC(50) values of 3.9, 15.2, 11.2, 5.9, and 4.7 μM, respectively. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-018-0154-1) contains supplementary material, which is available to authorized users.

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