Xylanilyticolides A–C, Three New Compounds from Cultures of the Actinomycete Promicromonospora xylanilytica YIM 61515

ABSTRACT: Three new lactones, xylanilyticolides A–C (1–3), were isolated from cultures of the actinomycete Promicromonospora xylanilytica YIM 61515. Their structures were elucidated by 1D and 2D NMR spectroscopic data in conjunction with HRESIMS analysis. Compound 1 exhibited potent cytotoxicities a...

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Autores principales: Wang, Zhen-Xiong, Qin, Shen, Xu, Li-Hua, Chen, He-Ping, Sun, Huan, Huang, Rong, Li, Zheng-Hui, Feng, Tao, Liu, Ji-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913047/
https://www.ncbi.nlm.nih.gov/pubmed/29441465
http://dx.doi.org/10.1007/s13659-018-0154-1
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author Wang, Zhen-Xiong
Qin, Shen
Xu, Li-Hua
Chen, He-Ping
Sun, Huan
Huang, Rong
Li, Zheng-Hui
Feng, Tao
Liu, Ji-Kai
author_facet Wang, Zhen-Xiong
Qin, Shen
Xu, Li-Hua
Chen, He-Ping
Sun, Huan
Huang, Rong
Li, Zheng-Hui
Feng, Tao
Liu, Ji-Kai
author_sort Wang, Zhen-Xiong
collection PubMed
description ABSTRACT: Three new lactones, xylanilyticolides A–C (1–3), were isolated from cultures of the actinomycete Promicromonospora xylanilytica YIM 61515. Their structures were elucidated by 1D and 2D NMR spectroscopic data in conjunction with HRESIMS analysis. Compound 1 exhibited potent cytotoxicities against five human cancer cell lines HL-60, A-549, SMMC-7721, MCF-7 and SW480 with the IC(50) values of 3.9, 15.2, 11.2, 5.9, and 4.7 μM, respectively. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-018-0154-1) contains supplementary material, which is available to authorized users.
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spelling pubmed-59130472018-04-30 Xylanilyticolides A–C, Three New Compounds from Cultures of the Actinomycete Promicromonospora xylanilytica YIM 61515 Wang, Zhen-Xiong Qin, Shen Xu, Li-Hua Chen, He-Ping Sun, Huan Huang, Rong Li, Zheng-Hui Feng, Tao Liu, Ji-Kai Nat Prod Bioprospect Original Article ABSTRACT: Three new lactones, xylanilyticolides A–C (1–3), were isolated from cultures of the actinomycete Promicromonospora xylanilytica YIM 61515. Their structures were elucidated by 1D and 2D NMR spectroscopic data in conjunction with HRESIMS analysis. Compound 1 exhibited potent cytotoxicities against five human cancer cell lines HL-60, A-549, SMMC-7721, MCF-7 and SW480 with the IC(50) values of 3.9, 15.2, 11.2, 5.9, and 4.7 μM, respectively. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-018-0154-1) contains supplementary material, which is available to authorized users. Springer Singapore 2018-02-13 /pmc/articles/PMC5913047/ /pubmed/29441465 http://dx.doi.org/10.1007/s13659-018-0154-1 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Wang, Zhen-Xiong
Qin, Shen
Xu, Li-Hua
Chen, He-Ping
Sun, Huan
Huang, Rong
Li, Zheng-Hui
Feng, Tao
Liu, Ji-Kai
Xylanilyticolides A–C, Three New Compounds from Cultures of the Actinomycete Promicromonospora xylanilytica YIM 61515
title Xylanilyticolides A–C, Three New Compounds from Cultures of the Actinomycete Promicromonospora xylanilytica YIM 61515
title_full Xylanilyticolides A–C, Three New Compounds from Cultures of the Actinomycete Promicromonospora xylanilytica YIM 61515
title_fullStr Xylanilyticolides A–C, Three New Compounds from Cultures of the Actinomycete Promicromonospora xylanilytica YIM 61515
title_full_unstemmed Xylanilyticolides A–C, Three New Compounds from Cultures of the Actinomycete Promicromonospora xylanilytica YIM 61515
title_short Xylanilyticolides A–C, Three New Compounds from Cultures of the Actinomycete Promicromonospora xylanilytica YIM 61515
title_sort xylanilyticolides a–c, three new compounds from cultures of the actinomycete promicromonospora xylanilytica yim 61515
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913047/
https://www.ncbi.nlm.nih.gov/pubmed/29441465
http://dx.doi.org/10.1007/s13659-018-0154-1
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