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Two New Indolyl Diketopiperazines, Trypostatins C and D from Aspergillus penicilliodes Speg.
Twelve indolyl diketopiperazines 1–12 were isolated from the mycelia culture of Aspergillus penicilliodes Speg., a dominant microorganism from the post fermentation process of ripe Pu-er tea. Their structures were elucidated by extensive spectroscopic methods. Among them, trypostatins C (1) and D (2...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Singapore
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913049/ https://www.ncbi.nlm.nih.gov/pubmed/29542040 http://dx.doi.org/10.1007/s13659-018-0156-z |
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author | Zhang, Han Zhu, Hong-Tao Wang, Dong Yang, Chong-Ren Zhang, Ying-Jun |
author_facet | Zhang, Han Zhu, Hong-Tao Wang, Dong Yang, Chong-Ren Zhang, Ying-Jun |
author_sort | Zhang, Han |
collection | PubMed |
description | Twelve indolyl diketopiperazines 1–12 were isolated from the mycelia culture of Aspergillus penicilliodes Speg., a dominant microorganism from the post fermentation process of ripe Pu-er tea. Their structures were elucidated by extensive spectroscopic methods. Among them, trypostatins C (1) and D (2) featuring with a rare methyl vinyl ketone side chain at C-2 are new compounds, while 3 and 4 were obtained for the first time from nature source. The isolates 3–12 did not show obvious cytotoxicities against five human cancer cell lines at a concentration of 40 μM. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-018-0156-z) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5913049 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-59130492018-04-30 Two New Indolyl Diketopiperazines, Trypostatins C and D from Aspergillus penicilliodes Speg. Zhang, Han Zhu, Hong-Tao Wang, Dong Yang, Chong-Ren Zhang, Ying-Jun Nat Prod Bioprospect Original Article Twelve indolyl diketopiperazines 1–12 were isolated from the mycelia culture of Aspergillus penicilliodes Speg., a dominant microorganism from the post fermentation process of ripe Pu-er tea. Their structures were elucidated by extensive spectroscopic methods. Among them, trypostatins C (1) and D (2) featuring with a rare methyl vinyl ketone side chain at C-2 are new compounds, while 3 and 4 were obtained for the first time from nature source. The isolates 3–12 did not show obvious cytotoxicities against five human cancer cell lines at a concentration of 40 μM. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-018-0156-z) contains supplementary material, which is available to authorized users. Springer Singapore 2018-03-14 /pmc/articles/PMC5913049/ /pubmed/29542040 http://dx.doi.org/10.1007/s13659-018-0156-z Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Zhang, Han Zhu, Hong-Tao Wang, Dong Yang, Chong-Ren Zhang, Ying-Jun Two New Indolyl Diketopiperazines, Trypostatins C and D from Aspergillus penicilliodes Speg. |
title | Two New Indolyl Diketopiperazines, Trypostatins C and D from Aspergillus penicilliodes Speg. |
title_full | Two New Indolyl Diketopiperazines, Trypostatins C and D from Aspergillus penicilliodes Speg. |
title_fullStr | Two New Indolyl Diketopiperazines, Trypostatins C and D from Aspergillus penicilliodes Speg. |
title_full_unstemmed | Two New Indolyl Diketopiperazines, Trypostatins C and D from Aspergillus penicilliodes Speg. |
title_short | Two New Indolyl Diketopiperazines, Trypostatins C and D from Aspergillus penicilliodes Speg. |
title_sort | two new indolyl diketopiperazines, trypostatins c and d from aspergillus penicilliodes speg. |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913049/ https://www.ncbi.nlm.nih.gov/pubmed/29542040 http://dx.doi.org/10.1007/s13659-018-0156-z |
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