A novel in vitro metric predicts in vivo efficacy of inhaled silver-based antimicrobials in a murine Pseudomonas aeruginosa pneumonia model

To address the escalating problem of antimicrobial resistance and the dwindling antimicrobial pipeline, we have developed a library of novel aerosolizable silver-based antimicrobials, particularly for the treatment of pulmonary infections. To rapidly screen this library and identify promising candid...

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Detalles Bibliográficos
Autores principales: Shah, Parth N., Shah, Kush N., Smolen, Justin A., Tagaev, Jasur A., Torrealba, Jose, Zhou, Lan, Zhang, Shiyi, Zhang, Fuwu, Wagers, Patrick O., Panzner, Matthew J., Youngs, Wiley J., Wooley, Karen L., Cannon, Carolyn L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913254/
https://www.ncbi.nlm.nih.gov/pubmed/29686296
http://dx.doi.org/10.1038/s41598-018-24200-w

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