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Aberrant salience network functional connectivity in auditory verbal hallucinations: a first episode psychosis sample

Auditory verbal hallucinations (AVH) often lead to distress and functional disability, and are frequently associated with psychotic illness. Previously both state and trait magnetic resonance imaging (MRI) studies of AVH have identified activity in brain regions involving auditory processing, langua...

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Autores principales: Mallikarjun, Pavan Kumar, Lalousis, Paris Alexandros, Dunne, Thomas Frederick, Heinze, Kareen, Reniers, Renate LEP, Broome, Matthew R., Farmah, Baldeep, Oyebode, Femi, Wood, Stephen J, Upthegrove, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913255/
https://www.ncbi.nlm.nih.gov/pubmed/29581420
http://dx.doi.org/10.1038/s41398-018-0118-6
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author Mallikarjun, Pavan Kumar
Lalousis, Paris Alexandros
Dunne, Thomas Frederick
Heinze, Kareen
Reniers, Renate LEP
Broome, Matthew R.
Farmah, Baldeep
Oyebode, Femi
Wood, Stephen J
Upthegrove, Rachel
author_facet Mallikarjun, Pavan Kumar
Lalousis, Paris Alexandros
Dunne, Thomas Frederick
Heinze, Kareen
Reniers, Renate LEP
Broome, Matthew R.
Farmah, Baldeep
Oyebode, Femi
Wood, Stephen J
Upthegrove, Rachel
author_sort Mallikarjun, Pavan Kumar
collection PubMed
description Auditory verbal hallucinations (AVH) often lead to distress and functional disability, and are frequently associated with psychotic illness. Previously both state and trait magnetic resonance imaging (MRI) studies of AVH have identified activity in brain regions involving auditory processing, language, memory and areas of default mode network (DMN) and salience network (SN). Current evidence is clouded by research mainly in participants on long-term medication, with chronic illness and by choice of seed regions made ‘a priori’. Thus, the aim of this study was to elucidate the intrinsic functional connectivity in patients presenting with first episode psychosis (FEP). Resting state functional MRI data were available from 18 FEP patients, 9 of whom also experienced AVH of sufficient duration in the scanner and had symptom capture functional MRI (sc fMRI), together with 18 healthy controls. Symptom capture results were used to accurately identify specific brain regions active during AVH; including the superior temporal cortex, insula, precuneus, posterior cingulate and parahippocampal complex. Using these as seed regions, patients with FEP and AVH showed increased resting sb-FC between parts of the SN and the DMN and between the SN and the cerebellum, but reduced sb-FC between the claustrum and the insula, compared to healthy controls.It is possible that aberrant activity within the DMN and SN complex may be directly linked to impaired salience appraisal of internal activity and AVH generation. Furthermore, decreased intrinsic functional connectivity between the claustrum and the insula may lead to compensatory over activity in parts of the auditory network including areas involved in DMN, auditory processing, language and memory, potentially related to the complex and individual content of AVH when they occur.
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spelling pubmed-59132552018-04-24 Aberrant salience network functional connectivity in auditory verbal hallucinations: a first episode psychosis sample Mallikarjun, Pavan Kumar Lalousis, Paris Alexandros Dunne, Thomas Frederick Heinze, Kareen Reniers, Renate LEP Broome, Matthew R. Farmah, Baldeep Oyebode, Femi Wood, Stephen J Upthegrove, Rachel Transl Psychiatry Article Auditory verbal hallucinations (AVH) often lead to distress and functional disability, and are frequently associated with psychotic illness. Previously both state and trait magnetic resonance imaging (MRI) studies of AVH have identified activity in brain regions involving auditory processing, language, memory and areas of default mode network (DMN) and salience network (SN). Current evidence is clouded by research mainly in participants on long-term medication, with chronic illness and by choice of seed regions made ‘a priori’. Thus, the aim of this study was to elucidate the intrinsic functional connectivity in patients presenting with first episode psychosis (FEP). Resting state functional MRI data were available from 18 FEP patients, 9 of whom also experienced AVH of sufficient duration in the scanner and had symptom capture functional MRI (sc fMRI), together with 18 healthy controls. Symptom capture results were used to accurately identify specific brain regions active during AVH; including the superior temporal cortex, insula, precuneus, posterior cingulate and parahippocampal complex. Using these as seed regions, patients with FEP and AVH showed increased resting sb-FC between parts of the SN and the DMN and between the SN and the cerebellum, but reduced sb-FC between the claustrum and the insula, compared to healthy controls.It is possible that aberrant activity within the DMN and SN complex may be directly linked to impaired salience appraisal of internal activity and AVH generation. Furthermore, decreased intrinsic functional connectivity between the claustrum and the insula may lead to compensatory over activity in parts of the auditory network including areas involved in DMN, auditory processing, language and memory, potentially related to the complex and individual content of AVH when they occur. Nature Publishing Group UK 2018-03-27 /pmc/articles/PMC5913255/ /pubmed/29581420 http://dx.doi.org/10.1038/s41398-018-0118-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Mallikarjun, Pavan Kumar
Lalousis, Paris Alexandros
Dunne, Thomas Frederick
Heinze, Kareen
Reniers, Renate LEP
Broome, Matthew R.
Farmah, Baldeep
Oyebode, Femi
Wood, Stephen J
Upthegrove, Rachel
Aberrant salience network functional connectivity in auditory verbal hallucinations: a first episode psychosis sample
title Aberrant salience network functional connectivity in auditory verbal hallucinations: a first episode psychosis sample
title_full Aberrant salience network functional connectivity in auditory verbal hallucinations: a first episode psychosis sample
title_fullStr Aberrant salience network functional connectivity in auditory verbal hallucinations: a first episode psychosis sample
title_full_unstemmed Aberrant salience network functional connectivity in auditory verbal hallucinations: a first episode psychosis sample
title_short Aberrant salience network functional connectivity in auditory verbal hallucinations: a first episode psychosis sample
title_sort aberrant salience network functional connectivity in auditory verbal hallucinations: a first episode psychosis sample
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913255/
https://www.ncbi.nlm.nih.gov/pubmed/29581420
http://dx.doi.org/10.1038/s41398-018-0118-6
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